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Is There Interaction Between Carbatrol And Apixaban?

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Posted on Fri, 8 Jul 2016
Question: HI, I have been taking caribitrol for seisures for years now my dr. has prescribed equlis blood thinner and
I see that the two are contraindicated because of reduced effectiveness of equils. How much reduced
effectiveness ? 50%, 10% 80% ?
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Answered by Dr. Ishu Bishnoi (59 minutes later)
Brief Answer:
Reduction in effectiveness

Detailed Answer:
Hi XXXX, thanks for asking from HCM.


I can understand your point. Use of carbamazepine (Carbatrol) and Equils (Apixaban) leads to drug interaction and reduces efficiency of each other. I am not going into details of the enzyme and pharmacology as it is complex.

Overall recommendation is - This combination must be avoided.

Reduction in Apixaban efficiency or exposure is approximately 50% according to European Medicines Agency. However, it will also depend upon dose of carbamazepine.

My advise is to ask your doctor to change your anti epileptic or blood thinner, so that no interaction occurs between two.

Hope you got your answer. If still in doubt, do let me know.
Thanks. Take care.
Above answer was peer-reviewed by : Dr. Yogesh D
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Answered by
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Dr. Ishu Bishnoi

Neurologist, Surgical

Practicing since :2007

Answered : 901 Questions

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Is There Interaction Between Carbatrol And Apixaban?

Brief Answer: Reduction in effectiveness Detailed Answer: Hi XXXX, thanks for asking from HCM. I can understand your point. Use of carbamazepine (Carbatrol) and Equils (Apixaban) leads to drug interaction and reduces efficiency of each other. I am not going into details of the enzyme and pharmacology as it is complex. Overall recommendation is - This combination must be avoided. Reduction in Apixaban efficiency or exposure is approximately 50% according to European Medicines Agency. However, it will also depend upon dose of carbamazepine. My advise is to ask your doctor to change your anti epileptic or blood thinner, so that no interaction occurs between two. Hope you got your answer. If still in doubt, do let me know. Thanks. Take care.