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Dr. Andrew Rynne
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Dr. Andrew Rynne

Family Physician

Exp 50 years

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Is taking Pristiq 50mg and Trazodone 25mg at night for sleep safe?

Answered by
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Dr. Olsi Taka

Neurologist

Practicing since :2004

Answered : 3649 Questions

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Posted on Tue, 6 Sep 2016 in Sleep Disorders
Question: Is taking Pristiq 50mg and trazodone 25mg at night for sleep safe?
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Answered by Dr. Olsi Taka 14 minutes later
Brief Answer:
Not safe.

Detailed Answer:
I read your question carefully and I understand your concern regarding drug interactions.

I am afraid that combination is not safe. Those are two antidepressants which both increase the levels of a neurotransmitter called serotonin and as a result cause what is called serotonin syndrome.

It is very rare but can be life threatening so for that reason their use together is not recommended and some other alternative must be used.

I remain at your disposal for further questions.
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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