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Is sinonasal carcinoma curable?

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Posted on Thu, 31 Jul 2014
Question: Hi ,
this is XXXXXXX my brother in law(age 27) is suffering with sinonasal carcinoma ,the following treatment was given
1. radiation for 33 days (5 days per week)
2.chemo for 5 times (weekly once)
then after he was discharged from hospital ,doctor suggested us to visit hospital after 30 days for review . today is 15th day after discharge still he is suffering with snoring, blocked nose and watered eyes,but he was not getting any headache and pain in nose.
My questions are
1.will it be cure ?
2.what is life expectancy for him ?
3.is there any better treatment apart from chemo and radiation?

and I forgot to tell u ,the stage of the cancer is III .

early answer will appriciate
doctor
Answered by Dr. Deepak Kishore Kaltari (1 hour later)
Brief Answer:
Combined chemo radiotherapy is preferred

Detailed Answer:
Hi
Welcome to Healthcare-Magic
Greetings of the day

Dear Mr XXXXXXX

The major modalities for treatment of cancer available are

1. Surgery
2. Chemotherapy
3. Radiotherapy

Surgery is not a preferred option in paranasal sinus carcionoma, any surgery done will not lead to complete removal of tumor and will also lead to disfigurement of face and further need for reconstructive surgery .
Combined treatment with chemotherapy and radiotherapy is preferred modality of treatment

Let me answer your questions one by one

1. As it is advanced cancer cure rates are less than 50 percent (it would be helpful if you could provide me complete Radiological report and Histopathology report). Radiological assessment after completion of chemo radiotherapy will decide based on whether tumor has responded

A. Histopathology grade of tumor

B. Ct scan assessment of extent of tumor involvement.



Kindly get back to me with following additional details for me to be able to guide you further

1. Kindly let me know the exact anatomical location of tumor
2. Duration of symptoms
3. Histopathology report
4. EBV status


Awaiting your response

Take care
Best regards
Dr Deepak XXXXXXX
MBBS, MS, MCh
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Deepak Kishore Kaltari (24 hours later)
Dear Dr. XXXXXXX XXXXXXX
please find the attached Tow Reports
1. Biopsy Report Before Treatment
2.Summary Report which was given By KIIMs Hospital at the time Discharge (JUNE 24th 2014 ). I Attached Summary Report in order 1 to 8.

In this Summary Report you can find the complete Radiological report and Histopathology report, as well as complete Blood Picture from Treatment Start Date to End Date on weekly basis.

Actually In November 2013 he got bleeding from nose he simply ignored to get treatment then after XXXXXXX 2014 and Feb 2014 also he got Bleeding from nose after that he went to a small clinic in city but there is no relief ,later in march 2014 he was getting Pain in nose ,Blocked nose ,watered eye and headache .then we connected to ENT specialist in care hospital in XXXXXXX after diagnosis we found the he was infected with Sinonasal carcinoma. After that he undergone to Radiation and chemo therapy from Apr 24th 2014 to Jun 24th 2014.

now his present Symptoms are also blocked nose and snoring only.no headache and pain in nose.

now My questions are
1.Please let me know will that tumor was responded well or not?
2.what is his life expectancy (why Iam asking again if we know his life time we can plan him to keep always happy. Please understand my worry, We will take it no problem)
3.And Suggest me what I can take further Step.







doctor
Answered by Dr. Deepak Kishore Kaltari (1 hour later)
Brief Answer:
It has poor prognosis

Detailed Answer:
Hi

Greetings

Sorry for late reply.
Sinonasal undifferentiated carcionoma (SNUC) has a very poor prognosis compared to other cancers originating.
Going by the report it is locally advanced lesion with no evidence of distant metastasis (spread). Even after combined therapy with Intesnity Modulated Radiotherapy (IMRT) and Chemotherapy the response rate is less.
Following are survival rates
1 year survival rate is 50 percent
2 year survival rate falls drastically to 19 percent
3 year survival rate is 6 percent

It just means that only 50 percent of individual survive 1 year after adequate therapy. I'm extremely sorry for this.

I hope just suggest you to be in regular follow up . Let him be in the 6 percent category and survives longer.

Wishing you and your family a very happy and healthy life .

Take care

Regards
Deepak
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
Answered by
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Dr. Deepak Kishore Kaltari

General Surgeon

Practicing since :2002

Answered : 3193 Questions

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Is sinonasal carcinoma curable?

Brief Answer: Combined chemo radiotherapy is preferred Detailed Answer: Hi Welcome to Healthcare-Magic Greetings of the day Dear Mr XXXXXXX The major modalities for treatment of cancer available are 1. Surgery 2. Chemotherapy 3. Radiotherapy Surgery is not a preferred option in paranasal sinus carcionoma, any surgery done will not lead to complete removal of tumor and will also lead to disfigurement of face and further need for reconstructive surgery . Combined treatment with chemotherapy and radiotherapy is preferred modality of treatment Let me answer your questions one by one 1. As it is advanced cancer cure rates are less than 50 percent (it would be helpful if you could provide me complete Radiological report and Histopathology report). Radiological assessment after completion of chemo radiotherapy will decide based on whether tumor has responded A. Histopathology grade of tumor B. Ct scan assessment of extent of tumor involvement. Kindly get back to me with following additional details for me to be able to guide you further 1. Kindly let me know the exact anatomical location of tumor 2. Duration of symptoms 3. Histopathology report 4. EBV status Awaiting your response Take care Best regards Dr Deepak XXXXXXX MBBS, MS, MCh