Is prolonged intake of Telmisartan associated with an increased risk of getting cancer?
I am taking telmisartan + hctz(80 mg+ 12.5mg) for hypertension for last 10 years...Recently there are safety concerns regarding use of ARBs and their association with cancer...Some studies say that there is increased risk of cancer while others say there is no risk of cancer..
What is the exact scenario in this regard?
Some studies suggest telmisartan has an anti tumour effect as well and it decreases cancer..This is very confusing.Kindly help.
no proven documentation so far.
Dear XXXXXXX hi and welcome to HCM!
As of ARBs , they are a safe class of anti hypertensives with no reported risk or tumorogenic behavior. studies , literature reviews, these are subject to many confounding factors, results to be taken how authentically depends upon subject selection, strength of the study, size of the study population, risk of the patients, and many other factors.
so far , no study has come up with confirmed report about oncogenic potential of ARBs. they are safe and a good class of molecules.
Some scientists also say that TELMISARTAN IS AN EXCELLENT CHOICE AS IT HAS MANY CARDIOPROTECTIVE AND RENOPROTECTIVE EFFECTS AS WELL...
What is the latest information you have doctor?
Do you prescribe telmisartan in your practice? Can i continue with this medicine?
sure you can continue with the molecule.
dear XXXXXXX yes i do prescribe telmisartan in my daily practice. And yes ARBs as a class, not telmisartan alone, are good renoprotective, cardioprotective molecules, more so in t2dm patients. telmisartan is an ARB and not ppar agonist. PPAR agonists are thiazolidenedione and glitazars.
studies can give many pleiotropic benefits of a molecule which come up as secondary end point of a study. those secondary end points do not defend or deny , they only suggest for further confirmation. more of, any benefit or any side effect of any molecule is always a class effect and not molecule effect, degree might vary depending upon receptor affinity, stability of the molecule and interactions.
in short you may confidently continue the telmisartan and HC combination.
my pleasure sir!
dear XXXXXXX hope ur doubts and fears are cleared.
Why my creatinine levels are high? Before starting medicines for hypertension my BP used to be 150/ 90 always..Now it remains 125/85 nearly always.
What may be the reason behind high creatinine levels?
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