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Is it safe to take Nuvigil along with Klonopin and Xyrem?

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Posted on Thu, 14 May 2015
Question: He is taking nuvigl?Z250 klonopin.xyrum bfn is that not date rape drug but they say it's for sleep and other sleep drugs I'm very concerned obviously about the interaction
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Answered by Dr. Chintan Solanki (1 hour later)
Brief Answer:
Nuvigil to reduce sleep while klonopin to increase sleep

Detailed Answer:
Hello,

Thanks fro writing to us.

You are talking about some male(probably your husband or boyfriend). He is taking Nuvigil(armodafinil) 250 mg, Knolopin(clonazepam) and xyrem(sodium oxybate).

Nuvigil is prescribed for alertness. It is used in narcolepsy, somnolence or depression.

Klonopin is benzodiazepie. It is used as anti anxiety in low dose while for sleep in high dose.

Xyrem is also used in narcolepsy to reduce day time sleepiness.

Interaction between among drugs are as follows.

Klonopin and xyrem preferably should not be used together.Either increases effects of the other by pharmacodynamic synergism. Both can cause Central nervous system depression.Sometime cause excessive drowsiness and dizziness which may be harmful.Discuss the issue with your treating doctor please.

No significant interaction between xyrum and nuvigil.

Nuvigil reduces sedation while klonopin increases sedation so dosing and indication are decided according to need.No significant direct interaction between them.


Hope I have answered your query, I will be happy to help further.

Regards,
Dr.Chintan Solanki.
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Answered by
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Dr. Chintan Solanki

Psychiatrist

Practicing since :2007

Answered : 2406 Questions

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Is it safe to take Nuvigil along with Klonopin and Xyrem?

Brief Answer: Nuvigil to reduce sleep while klonopin to increase sleep Detailed Answer: Hello, Thanks fro writing to us. You are talking about some male(probably your husband or boyfriend). He is taking Nuvigil(armodafinil) 250 mg, Knolopin(clonazepam) and xyrem(sodium oxybate). Nuvigil is prescribed for alertness. It is used in narcolepsy, somnolence or depression. Klonopin is benzodiazepie. It is used as anti anxiety in low dose while for sleep in high dose. Xyrem is also used in narcolepsy to reduce day time sleepiness. Interaction between among drugs are as follows. Klonopin and xyrem preferably should not be used together.Either increases effects of the other by pharmacodynamic synergism. Both can cause Central nervous system depression.Sometime cause excessive drowsiness and dizziness which may be harmful.Discuss the issue with your treating doctor please. No significant interaction between xyrum and nuvigil. Nuvigil reduces sedation while klonopin increases sedation so dosing and indication are decided according to need.No significant direct interaction between them. Hope I have answered your query, I will be happy to help further. Regards, Dr.Chintan Solanki.