Get your health question answered instantly from our pool of 18000+ doctors from over 80 specialties

145 Doctors Online
Doctor Image
Dr. Andrew Rynne

Family Physician

Exp 50 years

I will be looking into your question and guiding you through the process. Please write your question below.

Is cancer of the stomach hereditary?

Answered by
Dr. Tayyab Malik


Practicing since :2009

Answered : 819 Questions

Posted on Tue, 21 Mar 2017 in Digestion and Bowels
Question: My father died rather suddenly from stomach cancer at the age of 43. Because he died at a rather young age I was wondering if we should be concerned about a possible link with the HDGC gene, and whether we should get tested for this? Family cancer history on his side is as follows;

Dad's Mother had bladder cancer and had her bladder removed.
Dad's Dad died of lung cancer (believed to be from smoking) and secondary brain cancer
Dad's sister (only sibling) has had 2 melanomas removed.

I told this information to my doctor, who suggested that I get breath tested for the h.pylori bacteria in my stomach. I did this and the test showed up clear, but I want to understand what this means. Does this mean that I don't have a HDGC gene? Does it mean that I don't have stomach cancer? Should I continue to get these tests regularly? Should I tell all 3 of my brothers to get this test? Is there a test I can get specifically to check for HDGC, and should I get this test and tell my brothers to?
Answered by Dr. Tayyab Malik 9 hours later
Brief Answer:
HDGC at your age is extremely UNLIKELY. Genetic testing maybe considered

Detailed Answer:
Thanks for posting your query at HCM.
I read your question thoroughly and understood your concern.

H Pylori infection is a risk factor for developing gastric cancer but its NOT certain that all individuals with this bacteria would eventually develop cancer. NOT all strains of H pylori are infectious and/or carcinogenic. Anyhow, since you tested negative for H pylori, so its all good.

HDGC is a cancer that results from mutation in CDH1 gene.
Genetic testing for CDH1 maybe considered. Criterion for genetic testing ( CDH1) is any "one" of following:

- Two gastric cancer cases in a family regardless of age, at least one confirmed diffuse gastric cancer
- Diffuse gastric cancer in an individual under the age of 40
- Personal or family history (first or second degree relative) of diffuse gastric cancer and lobular breast cancer, one diagnosed under the age of 50

Patients at risk for HDGC are also at risk for breast cancer.
Therefore, in addition, your also advised to:

-Clinical breast examinations performed by a doctor or nurse every 6 months
- Regular breast imaging with mammograms OR ultrasound

Wish you good and sound health.
Any further questions are welcomed.

Best regards
Dr Malik
Above answer was peer-reviewed by : Dr. Yogesh D
Follow up: Dr. Tayyab Malik 16 hours later
Thank you for the information. However, I was hoping for more direct answers to my specific questions.

1) Given that I tested negative for h.pylori, does this mean that I don't have HDGC? How are the two related?

2) Is it still possible to have (or contract) stomach cancer when h.pylori is not present?

2) Given the family history information that I provided, would you personally recommend me and my brothers to undergo any specific testing for HDGC? Do you think we are at risk of HDGC?

Thank you.
Answered by Dr. Tayyab Malik 2 hours later
Brief Answer:
H pylori is NOT related to HDGC

Detailed Answer:
Thanks for getting back to me.

Answers to your queries as follow:
1. Negative for H pylori does nor warranty that one would not develop HDGC.
H pylori infection is NOT linked to development of HDGC

2 Yes, one may contract a stomach cancer even in the absence of H Pylori

3 Its better for you and your brothers to have Genetic testing (CDH1) to rule out HDGC IF :
your father was diagnosed with HDGC in his 30s
any other family member "alongwith your father" was diagnosed with gastric cancer,

Hope to answer your concerns.
Best regards

Dr Malik
Above answer was peer-reviewed by : Dr. Yogesh D
Follow up: Dr. Tayyab Malik 39 minutes later
Thank you! That is very clear.

One more question - do you have any idea why, given the information that I provided, my doctor would have advised for me to undergo the h.pylori breath test?

Thanks again.
Answered by Dr. Tayyab Malik 2 hours later
Brief Answer:
Though NOT for HDGC, but H pylori is a risk for gastric cancer

Detailed Answer:
Its pleasure to answer your concerns.

HDGC is one of the cancers that involves gastric cancer.

H.Pylori is designated as Class I carcinogen ( for gastric cancer but not HDGC) by the International Agency for Research on Cancer.

So, your treating Physician may have asked you to test for H pylori to rule out this risk factor. Though to rule out HDGC, one needs further testing as elaborated earlier.

Wish you good health

Feel free to clear any further doubts.
Direct question link

Best Regards
Dr Malik
Above answer was peer-reviewed by : Dr. Kampana

The User accepted the expert's answer

Share on
Question is related to
Diseases and Conditions ,   ,   ,   ,   ,  
Lab Tests

Recent questions on  Bladder cancer

doctor1 MD

very warm regards doctor, i feel a kind of ticklish irritation just at the junction of bladder opening and urethra and iam never able to empty my bladder completely.every time after micturition i have to wait for another minute to empty the bladder by urinating certain drops of urine atlast.these last drops too dont get out of the bladder completely.just when iam about to finish the urination i feel that urethra closes before iam totally able to empty my bladder and applying pressure too...doesnt has been my condition from September 2005.and till now the conditions have improved though but the problem still persists.i have warts like swelled Fordyce s spots on my scrotum for many years.iam 22 years.i got my urine tested in 2007 from a best urologist in India(from AIIMS).he was straight forward and said i had no infection and no stones after he read the results of the urine test.still i said i feel pressure in bladder he gave me Uromax capsules and antibiotics for 14 days after which the problem is still exactly the father was reluctant like hell to take me to a doctor and now after he took me once he s not going to take me again. should i go again myself and is it baldder cancer or will it develop into cancer??please answer as immidiately as possible

doctor1 MD

My 90 y/o father had a 2nd cystoscopy and they found 2 bladder cysts which the doctor wants removed as OP. He has no symptoms. The last time his BP was 185 and the hospital nurses had a hard time getting it down. He also has small vessel disease which can cause a stroke. Is this procedure necessary

doctor1 MD

My name is Brenda, 5'7" 180 lbs. I was diagnosed in 2004. Presented with only the left ear affected. Blood Work sent to Mayo Clinic, confirmed Anti Collagen II. In 2006 had some nasal issues from RP nothing since. I have had microscopic hematuria since 1999 ranging from 2+ to 6+, about 20 different urinalysis and never an infection. Occasionally protein 5+. Had a urine cytology in 2006, negative for malignant cells, had a cytology in Feb 2010, negative for malignant cells. Had cytology 3 weeks ago, atypical urothelial. Have had symptoms similar to Interstial Cystitis for 5 to 6 years. Seems to flare at different times. Good for months at a time. Currently in some type of flair. Urinating 15-20 times a day, lots of burning but urinalysis done on Monday just came. back with blood 3+, no infection. Had cystoscope in 2008 looked good no lesions but bladder was slightly inflamed. I have another cystoscope scheduled for July 18th. I am extremely nervous about the Atypical Urothelial cells but have some comfort that I am still here with hematuria for 12 years. Do you think the Atypical Cells could be caused by what appear to be symptoms of Interstial Cystitis, or do you think it is likely I have bladder cancer. I am going insane waiting. Only one urologist is our town of 20,000.00

doctor1 MD

I had bladder cancer and underwent a surgery to remove the bladder. A neao bladder was created that allowed me to urinate normally. Some prostate was also removed. Since surgery I have lost erection which is causing depression. What can be done to regain erection. Viagra did not work. Thanks a million.

doctor1 MD

I m freaking myself out that I have bladder cancer! I ve had frequent urination for about two months. Now I m having dull pains and cramps on my sides and lower abdominal

doctor1 MD

I am male 93 years young currently under treatment for bladder cancer cancerous material removed and now I am thru thte second of the six shot weekly program. my problem now is shortness of breath . my heart dr. just completed a neucular stress...

doctor1 MD

Just had my annual physical last month. All my numbers were good except my triglycerides were high. What's going on is I'm having to urinate a lot more than normal. No pain or blood in urine and its been going on for about two months. recently...