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Is A Z-pack Better Than Doxycycline In Treatment For Mycoplasma?

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Posted on Mon, 22 May 2017
Question: I was given 20 days worth doxycycline to treat mycoplasma but everything i read online says that zpak is more effective. is it safe to take them together? I have several boxes of zpak because it is over the counter here
doctor
Answered by Dr. Panagiotis Zografakis (8 minutes later)
Brief Answer:
doxycycline is better...

Detailed Answer:
Hello,

doxycycline is actually the preferred treatment for mycoplasma because of the increasing resistance of macrolides like azithromycin and others. If you've used it for 20 days then I guess you should be done by now!

Kind Regards!
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Panagiotis Zografakis (17 minutes later)
I am only half way through my prescription but from what I read online was that only half were successfully cured with the doxy. It said that 1 gram dose of zpak was less effective then taking the zpak as a 500mg first day and then 250mg for four days but that taking the 500mg and 250mg had a 95% success rate. The conclusion I saw online was that the best was the zpak but it did talk about the risk of resistance to the zpak. That is why i feel like i should take them both to be safe. However, As I thought about this i thought could the zpak cause a resistance that would also make the doxy resistant. I don't know if that's possible or even makes sense so that is why I asked if they could be taken together. I will finish the doxy but i have a zpak sitting in my drawer and if zpak doesn't effect the doxycycline then I was just going to start takeing the zpak now while finising to doxy to be safe.
doctor
Answered by Dr. Panagiotis Zografakis (1 hour later)
Brief Answer:
I believe that doxycycline is enough

Detailed Answer:
It is a fact that the recommended regimen for Mycoplasma pneumoniae is doxycycline 100mg twice daily for 7-10 days. Alternative regimens include the following:
- azithromycin (z-pak) 500mg on day 1 and 250mg once daily for the next 4 days (as you've already found on the internet)
- levofloxacin 750mg once daily for 5 days.

Doxycycline has achieved better cure rates than azithromycin. Despite that treatment with azithromycin is acceptable and considered reasonable and effective. Levofloxacin is also more effective than azithromycin.

I disagree using two antibiotics for many reasons.

Kind Regards!
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Panagiotis Zografakis (23 minutes later)
Thank you very much. I will follow your orders!!!
doctor
Answered by Dr. Panagiotis Zografakis (1 minute later)
Brief Answer:
you're welcome

Detailed Answer:
You're welcome, best wishes for a speedy recovery!
Note: For more detailed guidance, please consult an Internal Medicine Specialist, with your latest reports. Click here..

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
Answered by
Dr.
Dr. Panagiotis Zografakis

Internal Medicine Specialist

Practicing since :1999

Answered : 3809 Questions

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Is A Z-pack Better Than Doxycycline In Treatment For Mycoplasma?

Brief Answer: doxycycline is better... Detailed Answer: Hello, doxycycline is actually the preferred treatment for mycoplasma because of the increasing resistance of macrolides like azithromycin and others. If you've used it for 20 days then I guess you should be done by now! Kind Regards!