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Is Nuvigil Advisable When Diagnosed With Atrial Fibrillation?

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Posted on Fri, 25 Sep 2015
Question: My Dr just put me on Nuvigil 150 mg for being tired and weak after AFIB, reading the med guide it doesn't sound like I should be taking this. Also I have high blood pressure and hypothyroidism. Am on Flecamide.
doctor
Answered by Dr. Ilir Sharka (2 hours later)
Brief Answer:
Nuvigil is not advisable in your clinical conditions.

Detailed Answer:

Hello!

Welcome and thank you for asking on HCM!

I understand you concern and would like to explain that Nuvigil is shown to have a potential for inducing atrial fibrillation in treated patients (as it is an indirect dopamine receptor agonist binding to the dopamine transporter and inhibiting dopamine reuptake). So, from this side of view, I would not recommend that drug to you, if I were your treating physician.

From the other side, it may exacerbate also hypertension, besides other unpleasant side effects.

Regarding to your extreme tiredness and weakness, I advise to first review your actual thyroid status (as hypothyroidism is an important factor for generating your current complains) and optimally control your high blood pressure values.

In addition, a review of your cardiac ultrasound would reveal a possible decreased cardiac performance and associated valvular dysfunction (which may be responsible for tiredness, etc).

You should discuss with your prescribing doctor about these issues.

Hope to have been helpful to you!

If you have further uncertainties, feel free to ask again!

Greetings! Dr. Iliri



Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Ilir Sharka (17 minutes later)
Also I am taking sayvasa for blood thinning it says not to take if you have GOOD kidneys. I think I do. Is this a good drug for me?
I am taking levothyroxin 135 XXXXXXX and my blood test turn out good
doctor
Answered by Dr. Ilir Sharka (1 hour later)
Brief Answer:
You need to check your renal function first.

Detailed Answer:

Hi again!

Regarding your treatment wit hsavaysa (edoxaban), i ould explain that you are right!

Edoxaban isn't recommended (IT IS CONTRAINDICATED) in individuals with a normal renal function (creatinine clearance>90 ml/min), as it has been shown to increase the risk of ischemic stroke compared to other anticoagulants (like warfarin).

You need to check you renal function tests. If they result normal (CrCl>90 ml/min) then you need to discuss with your prescribing doctor for a safer anticoagulation alternative.

Your thyroid function seems to be well balanced, but you need to look after your hypertension and cardiac function (reviewing echo) as well.


Best regards,

Dr. Iliri
Note: For more detailed guidance, please consult an Internal Medicine Specialist, with your latest reports. Click here..

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Answered by
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Dr. Ilir Sharka

Cardiologist

Practicing since :2001

Answered : 9534 Questions

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Is Nuvigil Advisable When Diagnosed With Atrial Fibrillation?

Brief Answer: Nuvigil is not advisable in your clinical conditions. Detailed Answer: Hello! Welcome and thank you for asking on HCM! I understand you concern and would like to explain that Nuvigil is shown to have a potential for inducing atrial fibrillation in treated patients (as it is an indirect dopamine receptor agonist binding to the dopamine transporter and inhibiting dopamine reuptake). So, from this side of view, I would not recommend that drug to you, if I were your treating physician. From the other side, it may exacerbate also hypertension, besides other unpleasant side effects. Regarding to your extreme tiredness and weakness, I advise to first review your actual thyroid status (as hypothyroidism is an important factor for generating your current complains) and optimally control your high blood pressure values. In addition, a review of your cardiac ultrasound would reveal a possible decreased cardiac performance and associated valvular dysfunction (which may be responsible for tiredness, etc). You should discuss with your prescribing doctor about these issues. Hope to have been helpful to you! If you have further uncertainties, feel free to ask again! Greetings! Dr. Iliri