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Is KRAS mutation colon cancer resistant to chemotherapeutic protocols?

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Posted on Fri, 15 May 2015
Question: Is KRAS mutant colon csncer stage 4 usually resistant to chemotherapy ?
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Answered by Dr. Iven Romic Rommstein (1 hour later)
Brief Answer:
In KRAS poz cancer there is poor chemoth effect

Detailed Answer:
Hi and welcome.
Generally yes. Cancers positive to KRAS mutation are more resistant to almost all chemotherapeutic protocols, but some smaller part of such patient may still show some benefit of chemotherapy especially oxaliplatin based medications. However, in stage 4 with distant meastases and inooeprable liver lesions, there is generaly poor prognosis but it is worth to try with palliative measures. WIsh you good health. Regards

Above answer was peer-reviewed by : Dr. Raju A.T
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Answered by
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Dr. Iven Romic Rommstein

General Surgeon

Practicing since :2008

Answered : 13870 Questions

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Is KRAS mutation colon cancer resistant to chemotherapeutic protocols?

Brief Answer: In KRAS poz cancer there is poor chemoth effect Detailed Answer: Hi and welcome. Generally yes. Cancers positive to KRAS mutation are more resistant to almost all chemotherapeutic protocols, but some smaller part of such patient may still show some benefit of chemotherapy especially oxaliplatin based medications. However, in stage 4 with distant meastases and inooeprable liver lesions, there is generaly poor prognosis but it is worth to try with palliative measures. WIsh you good health. Regards