I don't think that exposure caused the mutation
Thanks for your query. I am sorry to know about your son. Alk mutation is found in 5% of lung cancer
. However, there is no known specific offending agent which causes this mutation. Also, any cancer cell
needs several mutations to turn into cancer, alk is only one of them. We are interested in alk as it can be targeted by a specific drug called crizotinib
, which your son is probably getting or will get later.
is still not standard in lung cancer, it is being studied in trials. Please check if your son can be enrolled in one of such trials. Otherwise, doing mesothelial protein expresssion will not help.
Hope I have answered your query. I will be available to answer further followup queries, if any.