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Is Fosamax effective in treating joints and muscle pain?

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Posted on Thu, 1 Jun 2017
Question: What is the mechanism through which Fosamax and similar drugs treating Osteoporosis cause skeletal, joint and muscle pain?
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Answered by Dr. Shafi Ullah Khan (1 hour later)
Brief Answer:
Supportive care

Detailed Answer:
Thank you for asking

I read your question and i understand your concern. Fosamex is a brand name for alendronate which are from bisphosphonates family which are calcium metabolism modifiers. With osteoporosis there is severe loss of calcium from bones and bones become fragile and alendronates tries to help and recover.

As far as muscle and joint pains are concerned, its not the side effect of alendronate, its the osteoporosis and age related arthralgias that is causing these discomforts . Alendronate is there to help , along with it some good analgesics and muscle relaxant can be tried to sort it out. Supportive care for pain relief is all one can offer. Please talk to your pain management doctor and let them help for the pain.

I hope it helps. Take good care of yourself and dot forget to close the discussion please.

Regards
Khan
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Follow up: Dr. Shafi Ullah Khan (13 hours later)
Then why do the manufacturers of Alendronate and Risedronate include in their list of serious side effects: "Some people who take these medications DEVELOP severe bone, joint or muscle pain"? Could it have something to do with depleting other areas of calcium by shifting it back into bone?
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Answered by Dr. Shafi Ullah Khan (10 hours later)
Brief Answer:
Alendronate side effects

Detailed Answer:
Thank you for getting back to me

Yes there are some black box warnings for alendronate. If people had the history of getting severe musculoskeletal pain with use of alendronate and needs to be discontinued but frequency of such people is less than 1 % of its users so quite rare. Yes alendronate depletes calcium reserves and re drives them to bone and causes hypocalcemia and is the common reason for such pains and discomforts. Supplemental use of calcium supplements and once in a month dosage of alendronate takes care of these symptoms. If there are any severe pain symptoms, or osteonecrosis of jaw symptoms then discontinuing it with your prescribers consult is wise.

As far as mechanism is concerned, alendronate binds to hydroxyapatite crystals in bone and inhibits osteoclast-mediated bone resorption; decreases mineral release and collagen or matrix breakdown in bone.

I hope it helps.
Regards
Khan
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Answered by
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Dr. Shafi Ullah Khan

General & Family Physician

Practicing since :2012

Answered : 3613 Questions

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Is Fosamax effective in treating joints and muscle pain?

Brief Answer: Supportive care Detailed Answer: Thank you for asking I read your question and i understand your concern. Fosamex is a brand name for alendronate which are from bisphosphonates family which are calcium metabolism modifiers. With osteoporosis there is severe loss of calcium from bones and bones become fragile and alendronates tries to help and recover. As far as muscle and joint pains are concerned, its not the side effect of alendronate, its the osteoporosis and age related arthralgias that is causing these discomforts . Alendronate is there to help , along with it some good analgesics and muscle relaxant can be tried to sort it out. Supportive care for pain relief is all one can offer. Please talk to your pain management doctor and let them help for the pain. I hope it helps. Take good care of yourself and dot forget to close the discussion please. Regards Khan