I wake up at night always within two hours of
Add prokinetic agent...
The symptoms suggest gastroesophageal reflux disease (GERD). I can see you are trying many means to prevent reflux. I would add a prokinetic agent like domperidone or levosulpride along with nexium. The combination of the two is more effective in treating / preventing GERD.
In addition, it would also be worthwhile to consider an endoscopy if it hasn't been done in the past.
Hope this helps. Let me know if you need clarifications.