I take Prozac daily and Xanax as needed. I was
I just need to sleep and am having trouble doing so.
Hello and welcome,
I am sorry you have flu! Hycodan cough syrup contains hydrocodone (an opiate which strongly suppresses coughing).
The interactions are between the hydrocodone and your two meds.
The problem with hydrocodone and Xanax is that they both cause central nervous system depression. Best to avoid this combination if possible.
The interaction between Prozac and hydrocodone is as you mentioned, the risk of serotonin syndrome - because hydrocodone can increase the blood level of serotonin from the Prozac. It would be rare, though, for this to happen from the amount of hydrocodone you would be getting from cough syrup. The combination is not considered an absolute contraindication but rather to "use with caution".
Although it occurs rarely, I'll write here the typical symptoms of serotonin syndrome which are agitation and hyperactivity, excessively increased muscle tone (hyperreflexia), fast heart rate, fast breathing, and diarrhea.
I hope this information helps.
Let me know if I can assist you further.
Xanax has a wide range for it's "half life" (the amount of time until half of it is out of a person's system) from 6-27 hours, with an average range of about 11 hours.
If you took the Xanax this morning, it is probably ok to take the Hycodan now.
I hope you feel better soon.