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I take Prozac daily and Xanax as needed. I was

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Posted on Fri, 8 Mar 2019
Question: I take Prozac daily and Xanax as needed. I was recently diagnosed with influenza a and given hycodan cough syrup. Are there any interactions between Prozac/Xanax and the cough syrup? I have heard of serotonin syndrome and I’m aware I do not need to take the cough syrup with Xanax.

I just need to sleep and am having trouble doing so.
Thanks!
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Answered by Dr. Bonnie Berger-Durnbaugh (1 hour later)
Brief Answer:
Information

Detailed Answer:
Hello and welcome,

I am sorry you have flu! Hycodan cough syrup contains hydrocodone (an opiate which strongly suppresses coughing).

The interactions are between the hydrocodone and your two meds.

The problem with hydrocodone and Xanax is that they both cause central nervous system depression. Best to avoid this combination if possible.

The interaction between Prozac and hydrocodone is as you mentioned, the risk of serotonin syndrome - because hydrocodone can increase the blood level of serotonin from the Prozac. It would be rare, though, for this to happen from the amount of hydrocodone you would be getting from cough syrup. The combination is not considered an absolute contraindication but rather to "use with caution".

Although it occurs rarely, I'll write here the typical symptoms of serotonin syndrome which are agitation and hyperactivity, excessively increased muscle tone (hyperreflexia), fast heart rate, fast breathing, and diarrhea.

I hope this information helps.

Let me know if I can assist you further.
Regards


Above answer was peer-reviewed by : Dr. Arnab Banerjee
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Follow up: Dr. Bonnie Berger-Durnbaugh (15 minutes later)
Thank you. What is the recommended time to wait after taking a minor dose of Xanax to take hycodan? Have a wonderful weekend! Thanks for you help.
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Answered by Dr. Bonnie Berger-Durnbaugh (1 hour later)
Brief Answer:
Information

Detailed Answer:
Xanax has a wide range for it's "half life" (the amount of time until half of it is out of a person's system) from 6-27 hours, with an average range of about 11 hours.

If you took the Xanax this morning, it is probably ok to take the Hycodan now.

I hope you feel better soon.
Above answer was peer-reviewed by : Dr. Nagamani Ng
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Answered by
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Dr. Bonnie Berger-Durnbaugh

General & Family Physician

Practicing since :1991

Answered : 3138 Questions

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I take Prozac daily and Xanax as needed. I was

Brief Answer: Information Detailed Answer: Hello and welcome, I am sorry you have flu! Hycodan cough syrup contains hydrocodone (an opiate which strongly suppresses coughing). The interactions are between the hydrocodone and your two meds. The problem with hydrocodone and Xanax is that they both cause central nervous system depression. Best to avoid this combination if possible. The interaction between Prozac and hydrocodone is as you mentioned, the risk of serotonin syndrome - because hydrocodone can increase the blood level of serotonin from the Prozac. It would be rare, though, for this to happen from the amount of hydrocodone you would be getting from cough syrup. The combination is not considered an absolute contraindication but rather to "use with caution". Although it occurs rarely, I'll write here the typical symptoms of serotonin syndrome which are agitation and hyperactivity, excessively increased muscle tone (hyperreflexia), fast heart rate, fast breathing, and diarrhea. I hope this information helps. Let me know if I can assist you further. Regards