I drink a fair amount of alcohol every day. Can
welcome to the 'Ask a Doctor' service.
Desvenlafaxine and alcohol share some common side effects like dizziness, drowsiness, etc. When taken together these side effects may become more evident. The same applies for many other drugs that may cause central nervous system depression in their combination with alcohol (or other drugs that have similar side effects).
I hope I've answered your question. Please let me know if you need further assistance.