How long does an antibiotic-loaded bone cement remain in the system?
There is no such time frame
Welcome to health care magic, I share your concern and I will try to help you out in best possible way.
Antibiotic-loaded bone cement was developed for the treatment of infected joint arthroplasties and for prophylaxes in total joint replacement in selected cases.
The use of antibiotic-impregnated cement spacers has improved the outcomes of the treatment of infection associated with total joint arthroplasty.
Bone cement is a polymer-based material composed of poly-methyl-methacrylate (PMMA) or copolymers, is a polymeric material commonly used for the fixation of the joint implants to the bone, which is mixed with appropriate antibiotic during surgeries and are left in the joints. The administered antibiotics will be released into surrounding tissue and gets dissipated gradually thus leaving no trace of drug. The idea is to prevent local infection. Hence there is no such time frame for duration of presence of antibiotics within the body so there is no need to fret over prolonged presence of antibiotics in body.
I hope this helps you.
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Dr. Naveen XXXXXXX
Had a knee replacement in November 2012 it went wrong, I have a cement spacer in my knee since July 2014. Was told today they will remove in end of April and put another one in. Currently can not walk without sticks, cannot bend leg, leg is 2 inch shorter than other one (wasn't like this before) the pain I'm in is horrendous I am struggling with life as its nearly 4 years now
New one will be put to reduce chances of local infection
I appreciate your follow up..
I'm sorry you've been through so much recently. Here are my thoughts about how to help.
Since your knee replacement went wrong, cement spacer was used to stabilize the joint, now subsequent evaluation of your knee would have mandated its replacement, as I told earlier, antibiotics mixed with cement would have dissipated. I am also sorry to say that, once knee replacement is done, not much can be done to restore normal functioning of knee like bending. So I suggest you follow the advice of your treating orthopedician and get best possible rehabilitative measures.
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