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How long does an antibiotic-loaded bone cement remain in the system?

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Posted on Sat, 14 May 2016
Question: Hi is there a maximum time an antibiotic cement spacer should be left in the body?
doctor
Answered by Dr. Naveen Kumar (36 minutes later)
Brief Answer:
There is no such time frame

Detailed Answer:
Welcome to health care magic, I share your concern and I will try to help you out in best possible way.
Antibiotic-loaded bone cement was developed for the treatment of infected joint arthroplasties and for prophylaxes in total joint replacement in selected cases.
The use of antibiotic-impregnated cement spacers has improved the outcomes of the treatment of infection associated with total joint arthroplasty.
Bone cement is a polymer-based material composed of poly-methyl-methacrylate (PMMA) or copolymers, is a polymeric material commonly used for the fixation of the joint implants to the bone, which is mixed with appropriate antibiotic during surgeries and are left in the joints. The administered antibiotics will be released into surrounding tissue and gets dissipated gradually thus leaving no trace of drug. The idea is to prevent local infection. Hence there is no such time frame for duration of presence of antibiotics within the body so there is no need to fret over prolonged presence of antibiotics in body.
I hope this helps you.
If you have any further query, I would be glad to help you.
If not, you may close the discussion and if possible you may rate the answer for me, so that I get a good feedback.


Dr. Naveen XXXXXXX
Medical Consultant.
Ebix, Inc.
YYYY@YYYY
Above answer was peer-reviewed by : Dr. Naveen Kumar
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Follow up: Dr. Naveen Kumar (8 minutes later)
Thank you for the answer.
Had a knee replacement in November 2012 it went wrong, I have a cement spacer in my knee since July 2014. Was told today they will remove in end of April and put another one in. Currently can not walk without sticks, cannot bend leg, leg is 2 inch shorter than other one (wasn't like this before) the pain I'm in is horrendous I am struggling with life as its nearly 4 years now
doctor
Answered by Dr. Naveen Kumar (18 minutes later)
Brief Answer:
New one will be put to reduce chances of local infection

Detailed Answer:
I appreciate your follow up..
I'm sorry you've been through so much recently. Here are my thoughts about how to help.
Since your knee replacement went wrong, cement spacer was used to stabilize the joint, now subsequent evaluation of your knee would have mandated its replacement, as I told earlier, antibiotics mixed with cement would have dissipated. I am also sorry to say that, once knee replacement is done, not much can be done to restore normal functioning of knee like bending. So I suggest you follow the advice of your treating orthopedician and get best possible rehabilitative measures.
thank you.

regards

Above answer was peer-reviewed by : Dr. Naveen Kumar
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Answered by
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Dr. Naveen Kumar

General & Family Physician

Practicing since :2008

Answered : 154 Questions

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How long does an antibiotic-loaded bone cement remain in the system?

Brief Answer: There is no such time frame Detailed Answer: Welcome to health care magic, I share your concern and I will try to help you out in best possible way. Antibiotic-loaded bone cement was developed for the treatment of infected joint arthroplasties and for prophylaxes in total joint replacement in selected cases. The use of antibiotic-impregnated cement spacers has improved the outcomes of the treatment of infection associated with total joint arthroplasty. Bone cement is a polymer-based material composed of poly-methyl-methacrylate (PMMA) or copolymers, is a polymeric material commonly used for the fixation of the joint implants to the bone, which is mixed with appropriate antibiotic during surgeries and are left in the joints. The administered antibiotics will be released into surrounding tissue and gets dissipated gradually thus leaving no trace of drug. The idea is to prevent local infection. Hence there is no such time frame for duration of presence of antibiotics within the body so there is no need to fret over prolonged presence of antibiotics in body. I hope this helps you. If you have any further query, I would be glad to help you. If not, you may close the discussion and if possible you may rate the answer for me, so that I get a good feedback. Dr. Naveen XXXXXXX Medical Consultant. Ebix, Inc. YYYY@YYYY