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How Long Does Mifepristone Take To Show Effect?

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Posted on Wed, 4 Mar 2015
Question: hello im 3 weeks 3 days pregnant..i took mifeprostone 400mcg orally n then after 24 hours i took 4 tablets of misoprostol each 200mcg sublingually ..i waited for 4 hours there was no bleeding but there were cramps.after 4 hours i took a second dose of 4 tablets of misoprostol 200mcg sublingually there is slight spotting but no bleeding but i have cramps..m extremely worried please help me ,thankyou!
there is a correction in the above query i took mifeprostone 400mg not 400mcg.thankyou
doctor
Answered by Dr. Manisha Jain (42 minutes later)
Brief Answer:
wait for 24 hours

Detailed Answer:
Hello dear, I understand your health issue.
Wait for at least 24 hours and in case you still don't start with abortion process then repeat 400 mg of misoprostol.
It takes 6-24 hours for abortion process to start and can last for another 24 hours.
So just wait until 24 hours, no active treatment needed till then.
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Manisha Jain (14 hours later)
hello doc,
i waited for 24 hours and there is still no bleeding,though iam still having mild cramps.Il take 400mcg misoprostol again as u have asked me to wait for 24 hours and repeat the dose.Which route should i preferably take the misoprostol?sublingually or vaginally?which is more effective? and what if the abortion process doesnt start after this dose of misoprostol what iam i supposed to do???
THANKYOU.
doctor
Answered by Dr. Manisha Jain (2 hours later)
Brief Answer:
vaginal route

Detailed Answer:
Take misoprostol 400 ug vaginally and then rest for at least 2 hours.
In case abortion process fails to start in next 24 hours then you will need to get an ultrasound done at the earliest.
Take care
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Manisha Jain (2 hours later)
Its been two hours since i took misoprostol 400mcg vaginally..no bleeding till now..m worried can this pregnancy be ectopic? im just 25 years old and i dont qualify under the risk factors of ectopic pregnancy. in the past i got aborted twice using abortion pills and they worked ..this is third time...can this affect my health ..m concerned please help
doctor
Answered by Dr. Manisha Jain (37 minutes later)
Brief Answer:
wait for bleeding

Detailed Answer:
Yes mam, there can be a possibility of ectopic pregnancy in case you still don't abort after this dose also.
No further misoprostol should be taken now and rather you should opt for surgical evacuation of uterus but that too after ultrasound confirmation of intrauterine pregnancy.
I know this information is going to make you a little upset bit right treatment will help you to maintain good reproductive health in future.
Moreover if everything goes fine in this abortion process then shift to a regular method of contraception like oral pills.
All the best.
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Manisha Jain (25 minutes later)
can you tell me the signs and symptoms of ectopic pregnancy? and how should it be treated?
doctor
Answered by Dr. Manisha Jain (2 hours later)
Brief Answer:
ectopic pregnancy is unlikely

Detailed Answer:
Ectopic pregnancy presents as slight abdominal pain with mild spotting usually but as you have already taken MTP kit these symptoms cannot be differentiated from each other.
Best way to differentiate between them is via ultrasound at this stage.
But most probably you will respond to this dose of misoprostol so don't be anxious as yet.
Ectopic pregnancy is a surgical emergency and thus if present then has to be removed from the body via major surgery.
Hope for the best.
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Manisha Jain (1 hour later)
HELLO DOC,
Iam having chills and jaw ache after taking the dose of misoprostol.Is it normal??
doctor
Answered by Dr. Manisha Jain (8 hours later)
Brief Answer:
common to have these symptoms

Detailed Answer:
Yes dear, it is common and at times there can be slight fever too.
You can take tablet paracetamol thrice a day today and you will feel good.
Take care
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Manisha Jain (14 hours later)
hello doc,
i got the usg scan done.the report says no intrauterine or extrauterine gestation.i got the beta hcg test also done and the hcg levels in my blood are 337.90mlU/ml and mam there is very mild bleeding and i could see traces of tissues ..so what iam i supposed to do now? kindly suggest
THANKYOU
PS- iam uploading the reports for your reference mam
doctor
Answered by Dr. Manisha Jain (3 hours later)
Brief Answer:
complete abortion

Detailed Answer:
Hello dear, most probably this implies complete abortion.
There is nothing to worry just wait for a week and see for the bleeding pattern in case bleeding persists for more than a week then get the ultrasound repeated.
Just rest and take good diet.
All the best
Note: Revert back with your gynae reports to get a clear medical analysis by our expert Gynecologic Oncologist. Click here.

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
Answered by
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Dr. Manisha Jain

OBGYN

Practicing since :2007

Answered : 5136 Questions

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How Long Does Mifepristone Take To Show Effect?

Brief Answer: wait for 24 hours Detailed Answer: Hello dear, I understand your health issue. Wait for at least 24 hours and in case you still don't start with abortion process then repeat 400 mg of misoprostol. It takes 6-24 hours for abortion process to start and can last for another 24 hours. So just wait until 24 hours, no active treatment needed till then.