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How can nighttime muscle cramps be treated while on Chlorthalidone?

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Practicing since : 2006
Answered : 1762 Questions
I have been diagnosed with fairly severe osteoporosis. Parathyroid normal. 24 hour urinary calcium too high. Endocrinologist says take chlorthalidone. But it causes muscle cramps throughout the night. I take calcium, magnesium and tried adding potassium last night. Still woke up with cramping. Is there anything else I can do? Either so I can continue with the chlorthalidone or any different idea about treating the osteoporosis?They want me to stay on the med for a month then recheck urinary calcium,
Answered by Dr. Mirjeta Guni 13 minutes later
Brief Answer:
about osteoporosis treatment;

Detailed Answer:
Hello and thank you for asking!
I have gone carefully through your concern.
Chlorthalidone is not a mefication to treat osteoporosis but it is a diuretic that helps preventing calcium loss by the kidneys reducing urinary calcium.
There are some classes of drugs ( except of fosamax you have used) efficient in treating osteoporosis; Prolia and Forteo are being used widely with a higher efficiency than bisphosphonates (forteo).
You can discuss with your treating physician if they are appropriate for you.
Hope the information will be helpful.
kind regards,
Above answer was peer-reviewed by
Follow-up: How can nighttime muscle cramps be treated while on Chlorthalidone? 1 hour later
Thank you. I was previously aware of the other meds. They don’t want to start prolia or forteo until they see if they can reverse the calcium loss.
I understand that.
But my questions remain:
1- is there any other way to stop peeing calcium than this med?
2- If not then is there anything I can do to stop the muscle cramping?
And 3- the underlying question would be why would a person eliminate calcium? My kidney function tests are normal.
Thank you
Answered by Dr. Mirjeta Guni 17 hours later
Brief Answer:
About high urinary calcium excretion:

Detailed Answer:
Welcome back!
Let me start from the third question, the causes of high urinary calcium are;
-Rapid progressive osteoporosis, immobilization, Vit D excess, hyperthyroidism, XXXXXXX disease, idiopathic familiar hypercalciuria ect. In your case it may be due to severe osteoporosis.
-Of course the treatment would consist in eliminating the cause, but if no cause is found or in your case that osteoporosis treatment an not be started, thiazid diuretics (that you are taking) or orthophosphate (2 gr phosphorus/day) may reduce 50% the urinary calcium elimination.
-to treat the cramps probably your physician will suggest to increase the dose of minerals (calcium, magnesium, potassium) depending on the blood test exams.

Wishing you good health.
kind regards,
Above answer was peer-reviewed by
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