Get your health question answered instantly from our pool of 18000+ doctors from over 80 specialties

167 Doctors Online
Doctor Image
Dr. Andrew Rynne

Family Physician

Exp 50 years

I will be looking into your question and guiding you through the process. Please write your question below.

How accurate is a 4th generation test for HIV?

Answered by
Dr. Kakkar S.


Practicing since :2002

Answered : 8379 Questions

Posted on Mon, 9 Nov 2015 in Sexually Transmitted Diseases
Question: How accurate is a 4th generation test for HIV?
Is Dr. Lal path lab reliable? I did hiv test from there. I gave blood just after lunch at XXXXXXX Received result through Web next day till evening. They said the test done from XXXXXXX XXXXXXX lab. Through customer care they confirmed it.
Answered by Dr. Kakkar S. 31 minutes later
Brief Answer:
It is a very reliable lab

Detailed Answer:
Hello. Thank you for writing to us

I have read your query and I have understood your concern.

Yes, Dr.Lal Path Lab is a trustworthy lab.
A screening test at Dr.Lal Lab for Hiv would usually include an assay for both circulating Hiv P24 Antigen and an Anti-Hiv Antibodies. This is the latest 4th generation test for Hiv screening. A negative test result for this screening combo test rules out Hiv from as early as 2 weeks onwards the last risky sexual contact; P 24 Antigen appears in circulation and is detectable as early as 2 weeks after Hiv infection.

Above answer was peer-reviewed by : Dr. Prasad
Follow up: Dr. Kakkar S. 4 hours later
I am 38 years male. I have unprotected sex with Commercial Sex worker on May 2014. After one week started granular pharyngitis with dry cough. After one year still it continues. Not for a single day I got relief. 
I tested for HIV 27th September 2014 (CMIA 3rd Gen), then 28th December 2014 (CMIA 3rd Gen), then 4th January 2015 (Tri dot method). All negative. 

Question 1. Are the test results conclusive? Is there any chance of HIV despite the negative result. (I did not have any further exposure). 
Question 2. I did the test in XXXXXXX private pathology lab called Serum Analysis Center Pvt Ltd and Tri dot test from a local lab. Are these labs reliable? 
Question 3. I did one more test on 4th August 2015 from Dr. Lal path Lab. It was 4th Generation test with Index value 0.1. Result negative. Is it a reliable pathology laboratory? I gave blood sample in XXXXXXX before lunch. Received result online next day evening. They said the test was done in New XXXXXXX  
Question 4. I did not consult with any HIV specialist, did all test by myself approached to lab. Are these results reliable? 

Very much under stress
Answered by Dr. Kakkar S. 12 hours later
Brief Answer:
Answers to specific questions

Detailed Answer:

Answer to question 1. Third generation tests are antibody based tests. These are all conclusive because they were well past the window period of detection for Hiv anibodies which is 3 months. These tests conclusively declare you negative for Hiv.

Answer to question 2. Yes, these are reliable labs.

Answer to question 3. Dr. Lal is a reliable lab. 4 th generation tests are superior to third generation tests because they can detect infection as early as 2-4 weeks after infection. This is because they detect both P 24 antigen (which appears earlier) as well as antibodies against Hiv. Apart from its advantage over 3rd generation test in terms of early detection of Hiv infection, it offers no other advantage over 3rd generation antibody tests.
Actually there was no need to do this test as you were conclusively declared negative by 3 rd generation tests.

Answer to question 4. No need to consult an Hiv specialist. You may however consult an ENT specialist fpr Pharyngitis.

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar

The User accepted the expert's answer

Share on
Question is related to
Diseases and Conditions ,   ,  
Lab Tests

Recent questions on  Dry cough

doctor1 MD

I have had diarrhea for 2 days and it sometimes will happen to leak into my underwear without me noticing throughout the day. I have been tired for abou two months, i can have 12 hours of sleep but be extremely tired all day. I have a sore throat and a dry cough until about last night which it is now a bit Flemish. I have lower back pains and my whole body aches. I have had severe headaches as well

doctor1 MD

Severe cough , its dry cough ...getting continuously...couldn t bear it since last three days. not stopping. using Ascoril-D syrup, Augmentin Duo-625 tablets. but no change. please help me. age - 26 female, weight 77kg, height 5ft 4 inch, previously six months back the same condition and cured with the above medicine

doctor1 MD

i am experiencing a pain at the upper right rib cage when i cough or sneeze, also when i lay down on either side of my body with shortness of breath. I had the flu and it left me with this dry cough and itchy throat and now i am experiencing the above mentioned symptoms. Althea

doctor1 MD

for the last five days I have had a dry cough which has caused a lot of strain on my stomach I still have the cough but the pain (strain) is in both my left and right sides it some times takes my breath but not to the extent that it worrys me, a Dr at local centre has given me 7day course of Amoxicillin capsules which I started taking today, As the pain in my sides is aggrevated by the cough and it really is painful when I cough I thought the Dr would have given some cough mixture to ease it but he told me the cough will clear its self, which do s not help me when I am in so much pain when the coughing starts. I am type2 diabetic and it is not easy to buy over the counter any cough mixture which would be safe to take. what can I do to ease this pain

doctor1 MD

I've had a cold from runny nose since Thanksgiving in the U.S. to now a cough the past four days. I lost my voice and its been about three days. It's a dry cough and kept me up all night yesterday. I think I am getting better if I rest my voice. I...

doctor1 MD

I had a dental crown done 3 weeks ago. The day after I had a white tongue and congestion in my throat and chest. I also have had a dry cough over a couple months. No fever 97.7, minor sore throat and no mucus has been coughed up. Lymoph nodes on...

doctor1 MD

Dear doctor thanks for your valuable reply however my further query is for last two weeks I have a mild rash under my eye which is persistent and is not going away...I had read somewhere in the webmd website that facial rashes are the first sign...