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What Do Epileptiform Discharges In Both Fronto-temporal Regions In An MRI Report Mean?

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Posted on Wed, 4 Oct 2023
Question: Hi,
This is XXXXXXX from XXXXXXX XXXXXXX This is with regard to my wife's health, she had seizure last Sunday that is on 29th April, 2018 between 2.30 - 3.15 PM. Seizure lasted for about 1-2 minutes & it took about 10-15 min to restore back her consciousness. She had her tongue bite & saliva oozing out.
Last night she hardly had 3 hours of sleep & the next day morning she didnt had her breakfast properly. Also, we have 3 years old daughter which she has to look after & the kid was little cranky on that day(29th April, 2018).

As per her health history, this is the second time she had the seizure. Last & first time was way back 9 years ago (while studying in college), she had a similar pattern of sleep (no proper sleep) & not taking food properly. But she didnt had her tongue bite that time. The medication she took was Encorate Chrono 300mg which was taken for about 2.5 years & left after that.

For the recent seizure, we did consult Neurologist here, who advised for MRI scan & EEG. MRI has come out to be normal but EEG says 'Abnormal suggestive of Epileptiform discharges in both Fronto-temporal regions' (i can share the EEG report, if required). Later Neurologist advised medication of Levipil 500 mg tablets (twice a day) for next 3 years.

We thought we should second opinion on this, so we would like to know how complicated/serious is this case & does my wife really need the above mentioned medication for 3 years, kindly advise.


Thanks, XXXXXXX
doctor
Answered by Dr. Dr.Arnab (56 minutes later)
Brief Answer:
medication must be continued exactly as advised...

Detailed Answer:

Hello,

I've gone through your query and understand your concerns for your wife,

I've checked the attached EEG report. From your description, this recent seizure episode seems to be a generalized tonic-clonic seizure (GTCS), it's good that the MRI and EEG were already done...

Please note that anti-epileptic medications (eg. Levipil in her case) are of utmost importance, and must be taken exactly as already advised by the Neurologist.

This is definitely serious as brain controls almost all functions of our body and such seizure activities, if not controlled in time, can temporarily or even permanently damage those affected regions of the brain. So, medications need to be continued. From time to time routine follow-up with the Neurologist should be done to ascertain her progress and further dose modifications.

Please let me know a few more details in regard:

-Was there any MRI/CT-scan done while she had those earlier seizure episodes in college? If yes, please provide those reports...

-This time, was the MRI done with contrast or plain? kindly upload just the Printed report of MRI also so that I can take a look at it in details...

-Was there any past history of trauma/any kind of head injury?

-Was there any other blood investigation done this time?

Please note that several factors like lack of sleep (in her case), prolonged fasting, dehydration, excessive heat (especially during the Summertime), too much stress are all aggravating factors for seizure activities so should always be avoided under any circumstances.

The treatment modality of seizures are improved quite a lot, but it's also important to find out the probable cause of seizures (further investigations may also be required). However, despite all the advancement, in nearly half of the cases, the cause of seizure still remains unknown.

Not to worry, as of now, just take the medications as advised by her Neurologist and avoid those stress factors as I've explained...

I've tried to make it as simple as possible for you to understand, let me know if there are any further doubts/queries.

Take Care
Kind Regards

Above answer was peer-reviewed by : Dr. Arnab Banerjee
doctor
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Follow up: Dr. Dr.Arnab (1 hour later)
Thanks for the reply Dr. XXXXXXX Banerjee.

PFB - answers to your queries:
-Was there any MRI/CT-scan done while she had those earlier seizure episodes in college? If yes, please provide those reports...
Ans: No, it was only EEG which was done.

-This time, was the MRI done with contrast or plain? kindly upload just the Printed report of MRI also so that I can take a look at it in details...
Ans: I will share the MRI Report soon as i dont have right now.

-Was there any past history of trauma/any kind of head injury?
Ans: No

-Was there any other blood investigation done this time?
Ans: No.

Also, please answer to my question below:
1. Whether she can conceive, can we plan for next child?
2. How long this medication has to be taken?
3. Whether she can drive 2-wheeler or 4-wheeler?
4. Someone should always be there to escort her now, if yes, then how long?
5. Most of the time, it will be my wife & our 3 years old daughter who are at home, how safe is this?
6. Is it possible to cure permanently via operation?
doctor
Answered by Dr. Dr.Arnab (49 minutes later)
Brief Answer:
follow as already advised...

Detailed Answer:
Welcome back,

Coming directly to your queries:

1. Yes she can, provided there are no other gynecological issues (however, it's not advisable to plan right away after this episode, take your time, give this a few weeks to settle down at first, afterward both of you can meet her gynecologist and decide accordingly)

2. This medication must be taken as long as advised by the Neurologist (can be few years can even be lifelong)

3. No, it's not at all advisable to drive any vehicles or even operate any kind of heavy/vibrating types of machinery

4. There's no fixed timeframe for that, but at least initial few weeks-months she should be under vigilance

5. Generally, it's safe, and your daughter will be growing older also, so eventually you can train her regarding the warning signs and symptoms to look out for in that scenario. But as already mentioned, initially for few weeks-months she should be under vigilance (perhaps someone from the parent's side/friends/family members should be present additionally)

6. Surgery is only considered when there's persistence/recurrence of seizure activities/ medications fail to control the seizure activities. There are specialized surgeries and several other investigations as well as targeted imaging studies (to focus/pinpoint the areas of the brain to determine the affected areas as well as to decide regarding the areas to spare). It'll be better to discuss regarding this with her NeuroSurgeon for further specifics.

Hope this helps...

Take Care
Kind Regards

Above answer was peer-reviewed by : Dr. Arnab Banerjee
doctor
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Follow up: Dr. Dr.Arnab (16 hours later)
Thanks Dr. XXXXXXX Sir.

Please answer below queries:

1. Would like to know is it just not enough to avoid triggering/aggravating factors such as lack of sleep, dehydration, lack of proper food in order to avoid seizures in the future, do we need medication as well?

2. Why seizure attack has re-occurred after such a long gap (9 years)? Is it only due to triggering factors such lack of sleep, stress, etc?
doctor
Answered by Dr. Dr.Arnab (2 hours later)
Brief Answer:
follow-up consultation...

Detailed Answer:
Welcome back,

1. No, it's not enough to just avoid those triggering factors. As already explained, medications need to be taken exactly as per the advice of the Neurologist.

2. As already explained earlier, further investigations may also be required to look for the possible cause (including a series of Sleep-awake EEG for a prolonged duration as well as specially focussed MRI/CT-scans). The Neurologist will be deciding this based on her present condition in due course of time. However, despite all the advancement, in nearly half of the cases, the cause of seizure still remains unknown.

Let me know if I can assist you further.

Take Care
Kind Regards

Above answer was peer-reviewed by : Dr. Arnab Banerjee
doctor
Answered by
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Dr. Dr.Arnab

Critical Care Specialist

Practicing since :2012

Answered : 1479 Questions

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What Do Epileptiform Discharges In Both Fronto-temporal Regions In An MRI Report Mean?

Brief Answer: medication must be continued exactly as advised... Detailed Answer: Hello, I've gone through your query and understand your concerns for your wife, I've checked the attached EEG report. From your description, this recent seizure episode seems to be a generalized tonic-clonic seizure (GTCS), it's good that the MRI and EEG were already done... Please note that anti-epileptic medications (eg. Levipil in her case) are of utmost importance, and must be taken exactly as already advised by the Neurologist. This is definitely serious as brain controls almost all functions of our body and such seizure activities, if not controlled in time, can temporarily or even permanently damage those affected regions of the brain. So, medications need to be continued. From time to time routine follow-up with the Neurologist should be done to ascertain her progress and further dose modifications. Please let me know a few more details in regard: -Was there any MRI/CT-scan done while she had those earlier seizure episodes in college? If yes, please provide those reports... -This time, was the MRI done with contrast or plain? kindly upload just the Printed report of MRI also so that I can take a look at it in details... -Was there any past history of trauma/any kind of head injury? -Was there any other blood investigation done this time? Please note that several factors like lack of sleep (in her case), prolonged fasting, dehydration, excessive heat (especially during the Summertime), too much stress are all aggravating factors for seizure activities so should always be avoided under any circumstances. The treatment modality of seizures are improved quite a lot, but it's also important to find out the probable cause of seizures (further investigations may also be required). However, despite all the advancement, in nearly half of the cases, the cause of seizure still remains unknown. Not to worry, as of now, just take the medications as advised by her Neurologist and avoid those stress factors as I've explained... I've tried to make it as simple as possible for you to understand, let me know if there are any further doubts/queries. Take Care Kind Regards