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Is Immediate Attention Necessary During Arrhythmia While On Lyrica, Tramadol, Codeine, Citalopram And Oxazepam?

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Posted on Thu, 7 Feb 2019
Question: Hi - I am copying my last question below as it has all the information about me in it. This new question is about irregular heartbeat. In XXXXXXX 2010 I had Wenckebach arrhythmia for the first time after starting Lyrica. Heart was missing every fourth beat at 4 am. In hospital, by midday it was missing each 8th beat then it went around 6 pm. I’ve been in hospital twice since then – the last time it was missing after 2, then 4, then 6, then 1 beats ie irregularly. This morning after taking more Tramadol than usual yesterday, it was missing irregularly 5 times each 15 seconds. I didn’t call an ambulance because I thought this has happened before and it’s been ok. What I need to know is… do I need to call an ambulance at times like this or if not, what should I do to help the heart? Thanks, Louise

Weight 92 kg Height 175 cm Age: 54
Diagnosed conditions: Fibromyalgia, C2/3 facet joint damage (MVA), C6/7 nerve root impingement (MVA), RSI right wrist (35 years), plantar fasciitis (comes and goes), sacro-iliac pain (comes and goes).
Recent blood test: bit low in Vitamin D.
Medications: Tramadol 100 mg/day, Codeine 30 mg day PRN, Citalopram 10 mg, Oxazepam 7.5 mg
Hi – I feel very breathless on little exertion and my heart rate increases a lot – for example just bending down to do up shoelaces. However, I can go for a 50 minute walk and not get too out of breath (except on hills). Having trouble sleeping for last two months as came off Stillnox after eight years on it. Sometimes used codeine, Temazepam and periactin to sleep. But last night took none of these and still feel very short of breath. Doctor has listened to chest – all ok. Might have a bit of reflux at night – not sure – but I think morning coughing could be due to that. Put on 10 kg in a six month period recently – it’s plateaued at 92 kg for about three months. Also feel pretty exhausted and tired and lacking motivation quite a bit of the time. Thanks
doctor
Answered by Dr. Ilir Sharka (45 minutes later)
Brief Answer:
I would recommend as follows:

Detailed Answer:

Hello,

Citalopram may trigger ectopic heartbeats. Besides it does not help with sleeping problems. For this reason, I would recommend switching from Citalopram to Mirtazapine before sleep (increase the dose gradually). It will also help with the pain.

I would also recommend performing some blood lab tests to investigate other possible causes that may trigger this situation:
- Complete blood count for anemia
- Blood electrolytes for possible imbalances
- Thyroid hormone levels for thyroid dysfunction

Regarding Tramadol, I would not recommend taking it for a prolonged time because it can lead to addiction and tolerance. For this reason, it is necessary to reduce the dose gradually until stopping.

Hope you will find this answer helpful. Let me know if I can assist you further.

Regards,
Dr. Iliri Sharka
Cardiologist
Above answer was peer-reviewed by : Dr. Arnab Banerjee
doctor
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Follow up: Dr. Ilir Sharka (23 hours later)
Dear Dr Iliri,

Many thanks for your responses! I have just had blood tests and the only things were Vit D was a bit low and thyroid a little bit low. Also trigylcerides up a bit and good cholesterol down a bit.

Actually I tried coming off Citalopram two years ago (been on it for 9 years now) but it was murder! Went on Mirtazapine at that time but it caused 12 kg weight gain in two months, water retention in ankles and a general feeling of being 'out of it' - apart from that - anxiety and depression and sleep wise, it was very good. But I found Citalopram better and went back on it. I would like to try to get off Citalopram very very slowly after getting off the Tramadol - the problem is I usually need more Oxazepam when I do it so it's all swings and roundabouts!

My rheumatologist suggested Cymbalta or Pristiq to help with the pain issues. What are they like for the heart side-effects?

Would it seem to you that because the Mobitz type I was even in it's irregularity to start with but is now uneven in its irregularity (ie losing beats after random numbers of beats, say 4 then 2 then 5 then 1) that it might have progressed to Mobitz type II? (been Dr Googling...) In this case, do you think I should be calling an ambulance when it happens or do you think it's ok to just ride it out at home until it stops? It usually only happens about once every six months when I take an unusual combination of medications.

So glad I'm talking with a cardiologist!

Many thanks for your help,
Louise
doctor
Answered by Dr. Ilir Sharka (18 hours later)
Brief Answer:
I would recommend as follows:

Detailed Answer:

Hello,

Regarding Cymbalta and Pristiq, they have similar adverse effects in the cardiac conductance system, like Citalopram: they may lead to QT prolongation and thus increased risk for cardiac arrhythmia. For this reason, I would not recommend switching from Citalopram to any of these drugs.

Regarding these episodes of cardiac arrhythmia, a prolonged ambulatory ECG monitoring or a loop recorder would help investigate the type of cardiac arrhythmia during those episodes.

Anyway, if these episodes last for a short period of time (seconds) and you have no other symptoms like shortness or breath, lightheadedness, etc., there is no need to go to the ER.

Otherwise, if these episodes are prolonged (some minutes or hours) and you experience the above mentioned symptoms, I would recommend going to the ER for a physical exam and a resting ECG, coupled with other blood lab tests (complete blood count, blood electrolytes).

Meanwhile, I would recommend you to periodically check every 6-12 months your vitamin D and thyroid hormone plasma levels, because these metabolic disorders have a high influence on the heart rhythm.

In case of deficiency, vitamin D supplements should be taken. The same is for thyroid hormone levels: medication may be needed in case of hypo or hyperthyroidism.

Hope you will find this answer helpful. Wishing all the best.

Regards,
Dr. Iliri Sharka
Cardiologist
Note: For further queries related to coronary artery disease and prevention, click here.

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
Answered by
Dr.
Dr. Ilir Sharka

Cardiologist

Practicing since :2001

Answered : 9536 Questions

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Is Immediate Attention Necessary During Arrhythmia While On Lyrica, Tramadol, Codeine, Citalopram And Oxazepam?

Brief Answer: I would recommend as follows: Detailed Answer: Hello, Citalopram may trigger ectopic heartbeats. Besides it does not help with sleeping problems. For this reason, I would recommend switching from Citalopram to Mirtazapine before sleep (increase the dose gradually). It will also help with the pain. I would also recommend performing some blood lab tests to investigate other possible causes that may trigger this situation: - Complete blood count for anemia - Blood electrolytes for possible imbalances - Thyroid hormone levels for thyroid dysfunction Regarding Tramadol, I would not recommend taking it for a prolonged time because it can lead to addiction and tolerance. For this reason, it is necessary to reduce the dose gradually until stopping. Hope you will find this answer helpful. Let me know if I can assist you further. Regards, Dr. Iliri Sharka Cardiologist