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Hello, I Am A 24 Year Old Female With A

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Posted on Tue, 23 Jun 2020
Question: Hello, I am a 24 year old female with a 12 month history of fatigue and muscle weakness which appears to be worsening, as well as generalized pruritus. Blood results have showed high B12 up to 2000 over this time, and more recently low gastrin, high basophils and eosinophils.
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Answered by Dr. Shailja Puri (3 hours later)
Brief Answer:
High vit B12 low gastrin,weakness & pruritis due to some metabolic disorder

Detailed Answer:
Hello,
Thanks for posting your query on Ask a doctor forum.
I have gone through the attached report.
Muscle weakness, pruritis, high vitamin B12 levels and low gastrin levels suggest an underlying metabolic disorder.
High vitamin B12 levels are seen in liver diseases and kidney diseases.
I suggest you to get liver and kidney function tests along with ultrasound abdomen and pelvis.
Low gastrin levels can be due to hypotrophy of gastrin secreting cells in stomach or excessive acidity in stomach.
I suggest you to consult a gastroenterologist for upper gastrointestinal endoscopy and stomach biopsy.
Pruritis can occur due to dry skin, raised bile salts etc.
I suggest you to get urine bile salts tested.
Muscle weakness can be due to generalized weakness.

Kindly, consult the respective doctors for above mentioned investigations for further management.

Thanks and take care
Dr Shailja Puri


Above answer was peer-reviewed by : Dr. Nagamani Ng
doctor
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Follow up: Dr. Shailja Puri (14 hours later)
Hello! Do the high basophil/ eosinophil levels suggest any particular metabolic disorder?

Thanks so much for your detailed response,
Kind regards,
Nikeisha
doctor
Answered by Dr. Shailja Puri (9 hours later)
Brief Answer:
Eosinophil and basophil count are in upper range

Detailed Answer:
Hello and welcome again,
The eosinophil count and basophil count are in upper range, however, it does not indicate any disease process.

Thanks and take care
Dr Shailja Puri
Above answer was peer-reviewed by : Dr. Nagamani Ng
doctor
Answered by
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Dr. Shailja Puri

Pathologist and Microbiologist

Practicing since :2006

Answered : 9158 Questions

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Hello, I Am A 24 Year Old Female With A

Brief Answer: High vit B12 low gastrin,weakness & pruritis due to some metabolic disorder Detailed Answer: Hello, Thanks for posting your query on Ask a doctor forum. I have gone through the attached report. Muscle weakness, pruritis, high vitamin B12 levels and low gastrin levels suggest an underlying metabolic disorder. High vitamin B12 levels are seen in liver diseases and kidney diseases. I suggest you to get liver and kidney function tests along with ultrasound abdomen and pelvis. Low gastrin levels can be due to hypotrophy of gastrin secreting cells in stomach or excessive acidity in stomach. I suggest you to consult a gastroenterologist for upper gastrointestinal endoscopy and stomach biopsy. Pruritis can occur due to dry skin, raised bile salts etc. I suggest you to get urine bile salts tested. Muscle weakness can be due to generalized weakness. Kindly, consult the respective doctors for above mentioned investigations for further management. Thanks and take care Dr Shailja Puri