Please refer below
Thanks for followup.
Muir-Torre syndrome (MTS) is associated with an inherited defect in one copy of a DNA (our genetic code
) repair gene. This leads to defect in DNA repair and can lead to cancer.
Criteria for the diagnosis of MTS include the presence of at least one skin tumor/cancer (either sebaceous adenoma, sebaceous epithelioma, or sebaceous carcinoma), and at least one visceral cancer (ie, colorectal, cancer of the uterus, small bowel, ureter, or renal pelvis
). Ovarian cancer
has also been reported in this. Fallopian tube cancer
is very similar to ovarian cancer, hence its association can't be ruled out.
But BRCA1 is a completely different entity and it leads to increased risks of breast and ovarian (or Fallopian tube) cancer. Chances of both in same patient is very unlikely.
Hence, you should also get tested for MTS. Isotretinoin
has been shown in small reports to be effective in prevention of skin cancers in MTS. But as this is a rare disease, no definite recommendations can be made. It has no role in BRCA mutaed patient.
Hope I have answered your query. I will be available to answer further followup queries, if any.