Question: I served in Afghanistan and have agoraphobia, panic disorder, I'm currently having a severe depressive episode, and PTSD. I am on 200mg Zoloft, 20mg Abilify, 1mg Ativan. The Zoloft and abilify do nothing. I have been on for 8 mths. The psychiatrist says I may be a poor metabolizer of depression meds. Based on my treatment I suspect I may have treatment resistant depression. My psychiatrist is weaning me off the Zoloft but is not sure what our next option should be. Zyprexa was the one med that worked but because of the weight gain I had to stop taking it and he won't put me back on it due to this. He listens to my ideas and research and I would like to know possible medications that might be worth bringing up to him. I've also read that with severe depression a low dose of a stimulant may improve the depression a little and aid with concentration and energy.. I was on strattera briefly but it didnt do much for me. Is this true and if so what med works best? I am at the point were I can barely leave my bed and sleep over 12 hours during the day. I don't want to end up in the hospital again.

Thank you Dr. I was having suicidal thoughts and ended up being hospitalized. They did end up putting me on Geodon and am feeling much better! Even when I was depressed I had a healthy appetite. I actually gained weight while depressed (a couple pounds) due to not working out. However with my new meds I have NO appetite. I have to force myself to eat because of the Geodon. My stomach is fine I just don't have much of an appetite. I have only been on the new meds for a week (some of them only a couple days). I am taking Geodon 60mg twice a day. Cogentin 2mg, Minipress 1mg, Paxil 20 mg, and Serequil 50 mg (for sleep). All of these meds are new for me. What could be causing my lack of appetite and is this temporary (since all the meds are new) or not?