Got VDRL test that is non reactive but TPHA is positive 1.16. Can I donate blood?
Thanks for the query
TPHA positive means you are having the active antibodies for syphilis. It is an indirect test to detect antibodies formed against the bacteria. The antibodies once formed never becomes negative and they remains life long however this does not mean that you are still suffering from the disease. it is a treatable condition and after succesful completion of treatment and resolution of symptoms, go for a serological test of syphilis. if it is negative for syphilis then you can go for sex with your wife without condom. however due to positive VRDL you cannot donate blood because it is already having antibodies that can cause allergic reactions
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Thanks for the reply
The Blood products are screened for antiHCV, HBsAg, HIV and VRDL. If you have these tests negative through screening process then you blood can be donated after a successful cross match with the recipient blood. There is no specific range for TPHA that defines the TPHA as negative. It can be either positive or negative. The ratio mentioned with the TPHA shows the reactivity of the antibodies. Your TPHA rang is almost in non-reactive range, however it can never be stated as non-reactive because it becomes reactive at any stage after the re-exposure to treponema pallidum bacteria which causes syphilis. Once become positive remains for years in the body defense mechanism. the serological test is EIA (enzyme ImmunoAssay)
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