Brief Answer: Yes, it has effect on gonadotropic functions. Detailed Answer: Hello, Thanks for your query. I have gone through your query and understood your concern. In my opinion, taking high dose of oxandrolone for 3 months will definitely influence on pubertal development because oxandrolone suppresses the gonadotropic functions of pituitary gland and may exert direct effect upon the testis. Hope this helped you. Thank you.