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Amlodipine is the antihypertensive drug that is most commonly associated with swelling of the limbs.
Losartan is not known to cause this problem. The most heart and blood vessels effect is dizziness and rarely low blood pressure on standing.

Swelling of the ankles is also not known to occur with the use of fish oil or vitamin c.

There are two levels of veins in the legs: (1) the superficial veins that lie close under the skin and the (2) deep veins that lie at a deeper level

These two levels of veins are connected by a valve that is to allow the blood to flow in one direction only , from the superficial veins to the deep veins and up to the heart to be pumped back out after collecting oxygen from the lungs.

In some persons the valves do not work as well as they should and blood pools in the superficial veins usually after prolonged standing, walking or sitting with the legs not propped up.

This is treated by elevation of the legs at periods during the day and the use of special stocking if necessary.

There are other causes of swelling of the legs such as :(1) heart disease or heart failure- this would usually be accompanied by symptoms such as shortness of breath, chest pain and palpitations

(2)Liver disease- this is because the liver is involved in making proteins in the body, if it is not working well then there is swelling

(3) kidney disease- because the kidneys are involved in ridding the body of excess fluid, if it is not working well, there is swelling of the limbs.

In these conditions there is usually a history of previous disease and the swelling would not be as easily responsive to elevating the legs..

You can consider visiting your doctor for an evaluation to rule out any other causes other than venous disease.

I hope this helps, feel free to ask any other questions

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