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Does intake of Metroprolol, Hydralazine and Finasteride help in treating urinary retention?

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Posted on Tue, 17 May 2016
Question: Yes I am concerned that my husband may be having some health problems, ie worse renal insufficiency and more problems with urinary retention. The drugs I am concerned about are Hydralazine 100 mg bid, Metroprolol 25 mg once q day,and Finasterlide 5mg once q day, His renal problem went from stage 2 to stage 3. ready for answer
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Answered by Dr. Muhammad Sareer Khalil (2 hours later)
Brief Answer:
Explained in detail

Detailed Answer:
Hello and welcome


Your concern is appreciated

The drugs you mentioned limte hydralazine which is do have side effects like painful or diificult urination and it is also known to cause 20% of patient taking 400mg per day to develop systemic lupus erythmatosus syndrome some expert may suggest to check patients acetylator status
Renal side effects are more present in idiopathic systemic lupus erythmatosus immune complex glomerulonephritis is rare in drug induced lupus
Rarely it may cause rapidly progressing glomerulonephritis accompanied by anemia positive ANA titer and positive anti-DNA antibody titer.
Metoprolol is a selective beta 1 adrenoreceptor blocker renal side effects are not there as such although it can cause frequent mucturation concomitently given with hydralazine lead to increase concentration of metprolol
No dose adjustments are required in renal impairment
Finasterlide is steriod resuctase inhibitor
And it has definately effects on renal functions and its dose is adjusted in patient with renal insufficiency

Regarding decrease renal insufficiency other factors like old age as with age number of funtioning nephrons decreases and the enlarged prostate can cause back preasure on the urinary system and effect kidney fuction. So these all can contribute to the decrease renal functions.


Hope it helps
Thanks

wishing you best of health

let me know if you have any query

Please consult your doctor before taking any further course of action

Dr M.S Khalil
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Answered by
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Dr. Muhammad Sareer Khalil

General & Family Physician

Practicing since :2012

Answered : 2909 Questions

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Does intake of Metroprolol, Hydralazine and Finasteride help in treating urinary retention?

Brief Answer: Explained in detail Detailed Answer: Hello and welcome Your concern is appreciated The drugs you mentioned limte hydralazine which is do have side effects like painful or diificult urination and it is also known to cause 20% of patient taking 400mg per day to develop systemic lupus erythmatosus syndrome some expert may suggest to check patients acetylator status Renal side effects are more present in idiopathic systemic lupus erythmatosus immune complex glomerulonephritis is rare in drug induced lupus Rarely it may cause rapidly progressing glomerulonephritis accompanied by anemia positive ANA titer and positive anti-DNA antibody titer. Metoprolol is a selective beta 1 adrenoreceptor blocker renal side effects are not there as such although it can cause frequent mucturation concomitently given with hydralazine lead to increase concentration of metprolol No dose adjustments are required in renal impairment Finasterlide is steriod resuctase inhibitor And it has definately effects on renal functions and its dose is adjusted in patient with renal insufficiency Regarding decrease renal insufficiency other factors like old age as with age number of funtioning nephrons decreases and the enlarged prostate can cause back preasure on the urinary system and effect kidney fuction. So these all can contribute to the decrease renal functions. Hope it helps Thanks wishing you best of health let me know if you have any query Please consult your doctor before taking any further course of action Dr M.S Khalil