Does having factor V Leiden increase the risk of thrombosis while on oral contraceptives?
being heterozygous for Leiden factor does increase your risk for thrombosis but only mildly so. Using progestin only contraceptives (mini-pill) may increase the risk further but not that much to make a big difference. Adequate studies are lacking regarding this subject but although there seems to be a slight increase in the risk, the absolute risk seems to be comparable to individuals not taking the mini-pill. So, for someone without a history of thrombosis it's probably not contraindicated. Please remember that smoking increases the risk for thrombosis, particularly with concurrent contraceptive use. Also the higher the age, the higher the risk. The risk for a 20 years old woman is much lower than the risk for a woman at her 40s.
it's the same...
Although not enough studies are available, the risk seems to be low for every progesterone only contraceptive method. The risk is higher for every method but the absolute risk is not high enough to be considered unsafe. I'm not aware of any studies addressing the aspirin issue. Aspirin is supposed to reduce thrombosis by preventing the formation of platelet clots. Leiden factor is involved in the coagulation cascade which is a different system, but aspirin may still provide some benefit. There is no therapeutic indication for this purpose though. Low molecular weight heparins are indicated for various causes of thrombophilia but factor V Leiden (heterozygous) is not one of them.
the same applies here
NSAIDs like ibuprofen may increase the relative risk but the absolute risk is still low for a heterozygous Leiden individual without any prior thrombotic event. So, although their use should be avoided for various reasons, there's no absolute contraindication.