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Does Combination Of Estrogen And Progesterone Cause Health Issues In Elderly Women?

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Posted on Wed, 2 Jul 2014
Question: My physician suggested an estrogen ( only ) vaginal cream for women after 65. He said that the combo of estrogen and progesterone may cause health issues after that age. What do you think?
doctor
Answered by Dr. Binu Parameswaran Pillai (23 minutes later)
Brief Answer:
Hello

Detailed Answer:
Hello,

Good day.
Welcome to health care magic.com. Several studies have shown that oral hormonal pills do not really protect against heart disease or stroke ( contrary to popular belief). Infact, it was shown to cause some deleterious health effects.

However, in those who continue to have distressing hot flushes after menopause, use of oral hormonal pills are recommended for a brief period.

Estrogen vaginal cream is a low dose estrogen preperation and is used in atropic vaginitis ( dryness) in post menopause age and in ladies with recurrent urinary tract infection. Intermittent ( weekly twice or thrice) use of low dose vaginal cream is good and safe.

Progesterone is generally combined with estrogen in pills to avoid endometrial proliferation in ladies who have uterus intact. In ladies with out uterus ( those who had surgery), estrogen alone pills are used.

However, low dose estrogen cream doesnt really cause endometrial proliferation. So it may not be necessary to use a combined cream in your case. I hope i answered your question. If it is not clear, please feel free to ask me further.

Regards XXXXXXX

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Binu Parameswaran Pillai (1 hour later)
what is endrometrial proliferation
doctor
Answered by Dr. Binu Parameswaran Pillai (7 hours later)
Brief Answer:
Hello

Detailed Answer:
Hello,

Good day.

Endometrium is the inner lining of uterus. Before menopause, normal estrogen levels in a lady cause endometrium to grow ( endometrial proliferation). This sheds during menstural periods. In the absence of progesterone, mesntural periods may not happen regularly and this cause the endometrium to become thicker and thicker. This can give trouble later in life. However, this doesnt happen if the lady has regular menstural periods because of endometrial shedding with periods.
. After menopause, endometrium shrinks as well as your uterus and ovaries.

When you use estrogen alone ( in pills), the endometrium start to grow again. If you do not add progesterone, endometrium do not shed and it becomes thicker.

That is the logic behind giving a combined ( estrogen+progesterone) pill in a lady with intact uterus. However, when we use estrogen as a vaginal cream, the dose used in extremly low and this may not cause this endometrial growth.

Reards
Binu
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Binu Parameswaran Pillai (16 hours later)
Dr. XXXXXXX ..how about a skin cream with estriol....is that safe? Cannot find a natural vag cream which isn't a prescription.
doctor
Answered by Dr. Binu Parameswaran Pillai (7 hours later)
Brief Answer:
Hi

Detailed Answer:
Hello,

Welcome back.
Estriol repacement is considered to be safer. It is another type of estrogen derivativ.
however, you must check with the local authorities regardng the recommendations in your counry regarding estriol use.

To be XXXXXXX my experience with Estriol is very limited for the simple reason that it is not widely used here. However, many reports says that it is safer than estrogen pills.

Regards
Binu
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Binu Parameswaran Pillai (19 hours later)
ok thank you
very good information
one observation...don't call XXXXXXX women ladies regarding medical info.
call them women
the word ladies is used in a social or more casual setting
good day Dr.
doctor
Answered by Dr. Binu Parameswaran Pillai (5 hours later)
Brief Answer:
Hello

Detailed Answer:
Good day,

Thank yo very much for pointing out my mistake. English is not my mother toungue and i often make such mistakes. My Apologies.

regards
Binu
Note: For more information on hormonal imbalance symptoms or unmanaged diabetes with other comorbid conditions, get back to us & Consult with an Endocrinologist. Click here to book an appointment.

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
Answered by
Dr.
Dr. Binu Parameswaran Pillai

Endocrinologist

Practicing since :2003

Answered : 1439 Questions

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Does Combination Of Estrogen And Progesterone Cause Health Issues In Elderly Women?

Brief Answer: Hello Detailed Answer: Hello, Good day. Welcome to health care magic.com. Several studies have shown that oral hormonal pills do not really protect against heart disease or stroke ( contrary to popular belief). Infact, it was shown to cause some deleterious health effects. However, in those who continue to have distressing hot flushes after menopause, use of oral hormonal pills are recommended for a brief period. Estrogen vaginal cream is a low dose estrogen preperation and is used in atropic vaginitis ( dryness) in post menopause age and in ladies with recurrent urinary tract infection. Intermittent ( weekly twice or thrice) use of low dose vaginal cream is good and safe. Progesterone is generally combined with estrogen in pills to avoid endometrial proliferation in ladies who have uterus intact. In ladies with out uterus ( those who had surgery), estrogen alone pills are used. However, low dose estrogen cream doesnt really cause endometrial proliferation. So it may not be necessary to use a combined cream in your case. I hope i answered your question. If it is not clear, please feel free to ask me further. Regards XXXXXXX