Brief Answer: No need bothering so much Detailed Answer: Hi and thanks for the query, from your description and normal exams or work up that you did, there should not be ay thing serious and you really need not worry that much. A past medical history of a well controlled Hypothyroid state is already very good. Amitritiline for sure has several indications, including why the doctor did prescribe it to you. I am afraid however that what you describe really does not have much, in my opinion, to do with this drug. It s generally associated very different classical side effects. It might be important to note the events you have gone through lately. Especially your social life and mental state. Depression or anxiety or too much worry, on their own, can seriously affect appetite and some basic physiologic functions like stooling. This could change your eating habits. It might be necessary also to know if you just changed your environment (physical, social or work environment). Recent change in jobs could also affect your mental state and coneequently your appetite. In case all these are normal and you still experience such symptoms, another common functional pathology is irritable bowel syndrome, The normality of your laboratory tests, colonoscopy and ultrasound make this a possible candidate to explain your symptoms. I do think you need not bother much for now. Improve or increase amount of exercise you do, discuss and spend more time with trusted friends and be compliant to your treatment. IN case despite these physical measures symptoms persist, the opinion of a gastroenterologist could be worth seeking. Thanks and kind regards as I wish you the best of health. Feel free asking specific follow up questions in case you need more help. I am will be more than happy sharing and making my humble contributions to your well being. Kind regards. DR Bain

---