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Does Trazadone Interact With Flexeril?

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Posted on Mon, 19 Sep 2016
Question: can i take trazadone with flexoril. Oxacodone keeps me awake at night and does not really help with the pain
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Answered by Dr. Michelle Gibson James (20 minutes later)
Brief Answer:
NO, combination should not be used

Detailed Answer:
HI, thanks for using healthcare magic

NO, these CANNOT be used together.

Both of these medications increase the levels of a chemical called serotonin. IN general it is not advised to use multiple medications that increase serotonin.

While small increases in serotonin is fine and actually the main way many medications work, very high levels can cause a lot of problems

Very high levels of serotonin can lead to serotonin syndrome which can be mild or severe in some cases.
It is associated with increased body temperature, increased heart rate, tremors , increased reflexes, muscle spasm, profuse sweating, seizures

You should not use this combination
I hope this helps, feel free to ask any other questions
Note: For more detailed guidance, please consult an Internal Medicine Specialist, with your latest reports. Click here..

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Answered by
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Dr. Michelle Gibson James

General & Family Physician

Practicing since :2001

Answered : 16808 Questions

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Does Trazadone Interact With Flexeril?

Brief Answer: NO, combination should not be used Detailed Answer: HI, thanks for using healthcare magic NO, these CANNOT be used together. Both of these medications increase the levels of a chemical called serotonin. IN general it is not advised to use multiple medications that increase serotonin. While small increases in serotonin is fine and actually the main way many medications work, very high levels can cause a lot of problems Very high levels of serotonin can lead to serotonin syndrome which can be mild or severe in some cases. It is associated with increased body temperature, increased heart rate, tremors , increased reflexes, muscle spasm, profuse sweating, seizures You should not use this combination I hope this helps, feel free to ask any other questions