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Does Tramadol interact with Flexeril?

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Posted on Sun, 6 Dec 2015
Question: Can I take 150mg of tramadol,15mg flexeril,500mg Tylenol and 75mg of Benadryl together, I have bilateral rotator cuff tears, I also have a controlled cardiac and hypertension history. I normally 7.5 mg norco 2 tabs TID PRN and have ran out about 4 days ago
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Answered by Dr. Michelle Gibson James (13 minutes later)
Brief Answer:
tramadol and flexeril can cause serious problems if used together

Detailed Answer:
HI, thanks for using healthcare magic

Tramadol and flexeril can possibly interact to cause serious problems. Both of these medications can potentially increase the levels of a chemical called serotonin, combined increased levels can increase the risk of complications such as seizures and other life threatening issues.

Generally recommended not to use together.
In addition the maximum dose of tramadol that is normally advised to be taken at one interval is 100mg, every 4 to 6 hours if needed.

There is a small interaction with benadryl and tramadol. The benadryl decreases the conversion of the tramadol to the active break down product.
This means that it can potentially decrease the effectiveness of the tramadol in some persons, this effect may not be significant for you.

The maximum single dose of the benadryl is usually up to 50 mg.

I hope this helps, feel free to ask any other questions
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Answered by
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Dr. Michelle Gibson James

General & Family Physician

Practicing since :2001

Answered : 16811 Questions

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Does Tramadol interact with Flexeril?

Brief Answer: tramadol and flexeril can cause serious problems if used together Detailed Answer: HI, thanks for using healthcare magic Tramadol and flexeril can possibly interact to cause serious problems. Both of these medications can potentially increase the levels of a chemical called serotonin, combined increased levels can increase the risk of complications such as seizures and other life threatening issues. Generally recommended not to use together. In addition the maximum dose of tramadol that is normally advised to be taken at one interval is 100mg, every 4 to 6 hours if needed. There is a small interaction with benadryl and tramadol. The benadryl decreases the conversion of the tramadol to the active break down product. This means that it can potentially decrease the effectiveness of the tramadol in some persons, this effect may not be significant for you. The maximum single dose of the benadryl is usually up to 50 mg. I hope this helps, feel free to ask any other questions