Brief Answer: Serotonergic drug needs a little precaution, Detailed Answer: Good day XXXX Thank you for asking. I am Dr S XXXXXXX and i would like to help you in your concerns for syndrome X and sertralin therapies. XXXX the syndrome X has an excellent prognosis providing coronaries are intact on angiography. The only thing to worry about is atherosclerosis and that is a long term complication easily manageable with a good lifestyle and dietary habits and a constant touch to a cardiologist. Now the sertralin is SSRI a good antidepressant and it has no correlation with syndrome X except it predisposes to the hypertension episodes in rare occasions. The only thing to worry about and leading to any cardiac trouble would be its misuse or its use with the forbidden drugs or food products containing tyramine or serotonins or any serotonergic drugs or MAOIs ( another antidepressants). watch out for the drug complications like bleeding profile and electrolytes derangements which indirectly can compromise heart and syndrome X presence further adds the precautions. Rest assured Sertralin wont harm syndrome X unless black box warnings which you dont have. Stay compliant with the medicines and with draw them slowly after consulting with the prescriber. Avoid self medication and seek a nutritionist to sort out all food ingredient containing serotonin and avoid them. Hope you see it in a right perspective. Take good care of yourself and don't forget to close the discussion please. regards

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