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Dr. Andrew Rynne

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Does Remeron interact with Melatonin?

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Dr. Alexander H. Sheppe

Psychiatrist

Practicing since :2014

Answered : 2241 Questions

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Posted on Fri, 17 Mar 2017 in Mental Health
Question: Hello, my name is XXXX XXXXXXX and I take 15 mg of abilify in the morning, 1 mg of klonopin three times a day, 5 mg of L-methylfolate two times a day, and 45 mg of remeron at night to help me sleep. I take 30 mg of remeron at first, and then when I wake up in the middle of the night I take 15 more mg of remeron. This doesn't always help me in falling back asleep so is it okay to supplement this with 6 mg of melatonin because I read on google that the combination of melatonin and remeron can cause death in males and people over 60. I am a 35 year old female, but this is still concerning to me. Here is the article where it says that: http://www.ehealthme.com/drug-interaction/mirtazapine/melatonin/
Please tell me if it's okay to take melatonin and remeron together, and if so, why it has death listed in the article.
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Answered by Dr. Alexander H. Sheppe 15 minutes later
Brief Answer:
Consultation

Detailed Answer:
Hello, and thanks for your question.

I can assure you that this combination is safe. A side effect has to be listed any time any person who experiences a symptom reports it. This means that common drugs such as aspirin and Tylenol also have death listed as a side effect, even though it is exceedingly unlikely. This is the same case here -- these medications are perfectly safe to take together.

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Dr. Sheppe
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