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Does Orencia Worsen Pulmonary Fibrosis?

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Posted on Wed, 18 Jan 2017
Question: I have ra

nd pulmonary fibrosis. Is orencia a safe treatment for my rate and not make my pulmonary fibrosis worse?
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Answered by Dr. Saddiq Ulabidin (2 hours later)
Brief Answer:
Direct worsening is impossible but it's also important to control RA

Detailed Answer:
Hi! Welcome to health care magic! Thanks for sharing your concerns with us. We will try to help you in best way possible. First of all, it is sad to know what you had gone through.

Based on the history you have shared, No direct relation is noted however, biological DMARDS, the group orencia belongs, can increase tendency of infections which may lead to fibrosis but that is rare sequelae of acute respiratory infections.

Otherwise only direct relation is a subgroup TNF alpha blockers whose tendency to increase fibrosis is still under dicussion and researches so far have shown very rare such incidences and still it's debatable that this increase was due to RA or the drug.

In any case, if RA is left uncontrolled it can worsen the fibrosis itself so it's better to control it and biological DMARDS are much better agents in that regard.

Wishing you a speedy recovery. If you have any more questions, feel free to ask. Regards.
Above answer was peer-reviewed by : Dr. Veerisetty Shyamkumar
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Answered by
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Dr. Saddiq Ulabidin

General & Family Physician

Practicing since :2011

Answered : 3941 Questions

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Does Orencia Worsen Pulmonary Fibrosis?

Brief Answer: Direct worsening is impossible but it's also important to control RA Detailed Answer: Hi! Welcome to health care magic! Thanks for sharing your concerns with us. We will try to help you in best way possible. First of all, it is sad to know what you had gone through. Based on the history you have shared, No direct relation is noted however, biological DMARDS, the group orencia belongs, can increase tendency of infections which may lead to fibrosis but that is rare sequelae of acute respiratory infections. Otherwise only direct relation is a subgroup TNF alpha blockers whose tendency to increase fibrosis is still under dicussion and researches so far have shown very rare such incidences and still it's debatable that this increase was due to RA or the drug. In any case, if RA is left uncontrolled it can worsen the fibrosis itself so it's better to control it and biological DMARDS are much better agents in that regard. Wishing you a speedy recovery. If you have any more questions, feel free to ask. Regards.