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    Does Memantine interact with Methotrexate?

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Posted on Thu, 27 Jul 2017 in Brain and Spine
Question: Is there an interaction between methotrexate and memantine?

I am taking 2 10mg of memantine per day and 6 tablets each Saturday of 15mg methotrexate. I began the methotrexate in mid XXXXXXX 2017 to control psoriasis.

I have taken methotrexate without problems during 2015.
I had no problems with memantine. Began taking it XXXXXXX 6, 2017.
I would describe symptoms as being paranoid, fear husband is leaving. Crazy.
doctor
Answered by Dr. Salah Saad Shoman 12 minutes later
Brief Answer:
Side effects of memantine

Detailed Answer:
Dear Ms, I have gone through your question and I understand your concerns but there are no reported interactions between Memantine and Methotrexate.

However, it is common for Memantine to cause the side effects of Confusion, hallucination, anxiety, depression, aggression, agitation, insomnia, delusion, sleep disorder, abnormal crying and psychotic reactions. These side effects can occur in up to 10% of patients using Memantine.

Please discuss this with your treating physician.

I hope you find this helpful, feel free to ask further.
Regards


Above answer was peer-reviewed by : Dr. Arnab Banerjee
doctor
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Follow up: Dr. Salah Saad Shoman 1 hour later
I made a mistake about Memantine. I began taking it in mid-April. Am I experiencing the cumulative effects of that medicine?
doctor
Answered by Dr. Salah Saad Shoman 23 minutes later
Brief Answer:
then Yes

Detailed Answer:
Dear Ms, yes most probably.

I hope you find this helpful.
Regards


Above answer was peer-reviewed by : Dr. Arnab Banerjee
doctor
Answered by
Dr.
Dr. Salah Saad Shoman

Internal Medicine Specialist

Practicing since :2004

Answered : 2446 Questions

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