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Does Excedrin Interact With Warfarin?

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Posted on Mon, 21 Aug 2017
Question: Hi, I take Warfarin. 2mg. I stay away from nsaids. However. I had a headache while I was out and someone gave me Excedrin. It worked so well. If I took it occasionally with it mess with my warfarin level. YYYY@YYYY
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Answered by Dr. Michelle Gibson James (33 minutes later)
Brief Answer:
aspirin in excedrin is the problem, risk of bleeding with warfarin

Detailed Answer:
HI, thanks for using healthcare magic

Excedrin contains acetaminophen (found in tylenol), caffeine and aspirin. It is the aspirin that would pose a problem because of the risk of bleeding associated with the combination of aspirin (and other NSAIDs) and warfarin

It would be risky to use any of these meds with warfarin.
It is possible that you may not have an effect at all but on the other hand it is also possible that a bleed might occur, it is unfortunately not something that can be predicted.

Potentially you can use a form of caffeine along with the tylenol or ask your doctor to prescribe another form of pain relief such as codeine or tramadol to help with your headaches.
These meds would not increase your bleeding risk.

I hope this helps, feel free to ask any other questions
Note: For further follow up on related General & Family Physician Click here.
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Answered by
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Dr. Michelle Gibson James

General & Family Physician

Practicing since :2001

Answered : 16808 Questions

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Does Excedrin Interact With Warfarin?

Brief Answer: aspirin in excedrin is the problem, risk of bleeding with warfarin Detailed Answer: HI, thanks for using healthcare magic Excedrin contains acetaminophen (found in tylenol), caffeine and aspirin. It is the aspirin that would pose a problem because of the risk of bleeding associated with the combination of aspirin (and other NSAIDs) and warfarin It would be risky to use any of these meds with warfarin. It is possible that you may not have an effect at all but on the other hand it is also possible that a bleed might occur, it is unfortunately not something that can be predicted. Potentially you can use a form of caffeine along with the tylenol or ask your doctor to prescribe another form of pain relief such as codeine or tramadol to help with your headaches. These meds would not increase your bleeding risk. I hope this helps, feel free to ask any other questions