Does DayQuil cause side effects when taken with NeoCitran Cold & Flu?
Yes,it might be due to drug allergy.
Yes, it is possible that your wife could have allergy to one or more drugs of neocitran which contains acetaminophen (NSAIDs analgesic and antipyretic), dextromethorphan(sedative cough suppressant) and phenylephrine (alpha agonist decongestant) used in cold and flu.
She might have type-I hyper sensitivity to one or more drugs of above which has caused hives and swelling of face as stated by you as it occurred following 2 hours of taking neocitran.
Also, neocitran and dayquil contains more or less same ingredients except for pseudoephedrine in place of phenylephrine but both have almost same effects.
She is being given treatment right now to combat this allergic symptoms and it is good too.
To diagnose drug allergy, detailed clinical history along with clinical examination by a allergy specialist is important.
Your doctor can also go for skin allergy test by injecting small amount of suspected drug beneath the skin and check for any mild to moderate visible reactions. Blood tests are also available but should be done in cases of severe allergy to a drug.
If there is confirmed allergy to a drug whether it mild or severe,complete avoidance of the drug is the best way to cure it.
Hope you have a understood it now.
Do ask me if there is any query further.
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