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Does Benadryl interact with Singulair?

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Posted on Tue, 13 Jun 2017
Question: I took a 10 mg tablet of Singular at 11pm can I now take a Benadryl? is there an bad interaction from those two medicines. taken close togehter?
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Answered by Dr. Bonnie Berger-Durnbaugh (44 minutes later)
Brief Answer:
Safe to take both diphenhydramine and montelukast together.

Detailed Answer:
Hello and welcome,

I checked on 2 drug interaction data basis, and no interactions were found between Benadryl (diphenhydramine) and Singulair (montelukast).

These 2 medications, while both are used for allergies, have different mechanisms of action. Benadryl is an antihistamine, meaning it blocks histamine receptors, and Singulair works on a different system (leukotrienes which are inflammatory mediators involved in allergies, asthma, and itching).

So it appears that it would be safe to take these 2 medications together.

I hope this information helps. Please let me know if I can provide further information.
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Answered by
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Dr. Bonnie Berger-Durnbaugh

General & Family Physician

Practicing since :1991

Answered : 3138 Questions

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Does Benadryl interact with Singulair?

Brief Answer: Safe to take both diphenhydramine and montelukast together. Detailed Answer: Hello and welcome, I checked on 2 drug interaction data basis, and no interactions were found between Benadryl (diphenhydramine) and Singulair (montelukast). These 2 medications, while both are used for allergies, have different mechanisms of action. Benadryl is an antihistamine, meaning it blocks histamine receptors, and Singulair works on a different system (leukotrienes which are inflammatory mediators involved in allergies, asthma, and itching). So it appears that it would be safe to take these 2 medications together. I hope this information helps. Please let me know if I can provide further information.