Get your health question answered instantly from our pool of 18000+ doctors from over 80 specialties

187 Doctors Online
Doctor Image
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

I will be looking into your question and guiding you through the process. Please write your question below.

Does ACTH level lab test for child consist of single or several secretion?

Answered by
Dr.
Dr. Michelle Gibson James

General & Family Physician

Practicing since :2001

Answered : 15705 Questions

default
Posted on Thu, 27 Dec 2012 in X-ray, Lab tests and Scans
Question: Dear Dr,

In an ACTH level lab test for child, does this consist of one single secretion or does it consist of several secretions resulting in a certain 'levels?

And how many pulses of adrenal testosterone does take place in the early morning ?

I hope i make sense, this is very important to me,

thanks and Best Regards,
XXXXXXX
doctor
Answered by Dr. Michelle Gibson James 14 hours later
Hi, thanks for using healthcare magic

ACTH is released from the pituitary gland and then promotes the release of cortisol from the adrenal glands

ACTH levels are normally highest in the morning (between 6 to 9 am) and lowest in the evening (6 to 11 pm), it begins to rise again about 2-3 am.
Normally it is released in pulses from the pituitary , about 40 pulses in a 24 hr period, with the greater release in the morning hours as stated previously. Normally only one sample is taken, there is an expected range for both the peak and low times of the day.Once the sample is taken it is compared to expected levels for that time period.

With regard to testosterone, most is secreted by the testes (95%) but a small amount may result from secretions from the adrenal glands.The adrenal gland secretes adrenal androgens which are male hormones, with a small amount of testosterone. The other androgens are converted to testosterone outside of the adrenal gland. The secretion at the adrenal is mediated by ACTH and it is secreted synchronously with cortisol (the hormone released from the adrenal in response to ACTH) in terms of its rhythm.
None of the studies indicate specifically how many pulses occur during the morning or evening, I am sorry about that.

I hope this information helps, feel free to ask any other questions
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
default
Follow up: Dr. Michelle Gibson James 7 hours later
Thank you Dr XXXXXXX for the advice,

i have one final queston, why is it that several secretions of hormones need to take place over sevral days before any effect is seen or visible.


Can low dose testosterone pulses produced in a single day cause effects such as hair growth? Or is the hair growth only visible after several days of production?

Thanks and Regards,
XXXXXXX
doctor
Answered by Dr. Michelle Gibson James 5 hours later
Hi,

With regard to the hair growth, testosterone is associated with growth of facial hair, axillary , pubic,chest,leg hair and can , in some persons, be associated with baldness.
It would take several days for hair growth to be apparent.

In terms of the first part of the question, it takes a while for the human body to respond to most types of hormones, only a few situations such as an adrenal crisis would an almost immediate response.

Feel Free to ask any other questions
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
default
Follow up: Dr. Michelle Gibson James 42 hours later
Thank you for you advice Dr XXXXXXX

I would like to ask further question. I understand that gonadarche starts two around two years after adrenarche. Does the increased adrenal androgen production in adrenarche lead to or affect the maturation of HPG axis?
I read somewhere that HPA maturation during adrenarche leads to HPG maturation after approx 2 years in a boys. What is the reason for this, is it due to cortisol secretion?
Best Regards,
XXXXXXX
doctor
Answered by Dr. Michelle Gibson James 4 hours later
Hi

Puberty starts as a result of increased levels of GnRH which is a hormone that is released from the hypothalamus.
GnRH is released in a pulsatile fashion from the hypothalamus, it stimulates the pulsatile release of the hormones FSH (follicle stimulating hormone ) and LH (luteinizing hormone) from the pituitary.
During childhood, there is inhibition of GnRH release and after a period this inhibition is reduced and GnRH levels increase.


Although there appears to be a time link between adrenache and gonadarche, the two are not actually linked, they are two separate events.
Adrenarche is independent of gonadarche .It is caused by maturation of a part of the adrenal cortex which results in an increase in adrenal androgens, the increase in the blood levels of the adrenal androgens start at age 5 or 6 and typically manifest about 2 yrs later.
At this present time the reason or the initiating factor for adrenarche is presently not known.

Hope this is helpful to you
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
premium_optimized

The User accepted the expert's answer

Share on
Question is related to
Drug/Medication ,   ,  
Medical Topics ,   ,  

Recent questions on  Neuroendocrinology

doctor1 MD

i AM AN 82 YEAR OLD MALE. MY PLATELET COUNT IS 30. MY ENDOCRONOLOGIST ADVISED ME TO TAKE TESTOSTERONE EVERY 2 WEEKS TO FEEL STRONGER & MORE ALIVE. HOWEVER, MY HEMATOLOGIST SAYS IT IS LOWERING THE PLATELET COUNT, AS i HAVE ITP. IS IT IN FACT DANGEROUS TO CONTINUE THE TESTOSTERONE SHOTS? I ALSO HAVE FIBRILATION - UNEVEN HEART BEAT. ALSO, I HAD A STROKE ABOUT 10 YEARS AGO. I WOULD APPRECIATE AN OPINION.

doctor1 MD

I was recently told I have empty sella found on a MRI. Also found low testosterone. I feel very fatiuged and can't handle stress very well. This has been going on for 3 to 5 years. Could I have a pituitary problem affecting other hormones such as cortisol. Thanks Jim C.

doctor1 MD

Sir, I am experiencing continuing hair loss (thinning to scalp area) approximately three months after discontinuing the use of Androgel for low testosterone. I am 53 y/o and had a full head of hair before using Androgel for two months. What can I do to stop/reverse hair loss? Thank You.

doctor1 MD

I was born September 1970



I was on

Testosterone Cypionate 200mg/cc. The weekly injection is .75cc

I STARTED TAKING TESTOSTERONE ON 3-25-11

I STOPPED TAKING TESTOSTERONE ON 7-13-11



On 6-24-11 my estradol was 69. My total testosterone was 639 , my free testosterone was 149.5.



How long after stopping testosterone will it and estradol go out of my system. In what month will I have normal healthy sperm ready to be used for ICSI IVF.

doctor1 MD

Hi. When I was younger I had steroid treatment to increase my height, as steroid is known to increase growth hormones in adolescent boys. Now I have anxiety this treatment had effect on my bone, and the effects are permanent. Do bones renew and...

doctor1 MD

I take.10 synthroid and .15 hydrocortisone daily. I recently had blood test and cortisone without meds was .6 and my Free T4 was low at .98. I have suffered for over 1.5 months with dry mouth syndrome . I saw an ENT who told me to suck on lemon...

doctor1 MD

I, my name is XXXXXXX 45 years old, recently i was diagnosed by my doctor to have mood disorder with depression due to stress and fatigue from work... That result in a 3 1/2 months stop from work. Then he prescrided me this medication you must...