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Do The Following Test Reports Suggest Kidney Transplant?

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Posted on Mon, 17 Oct 2016
Question: Hello doctor,

Good evening !

This is to ask you if Pre Transplant DSA crossmatch says class 1 (negative) , class ii (positive), PRA class 1 (moderate positive), class ii (Strong positive)...CDC (negative)...what does this mean? Can we go ahead with kidney transplant ?
doctor
Answered by Dr. Matthew J. Mangat (2 days later)
Brief Answer:
Reports point to incompatibility of transplant.

Detailed Answer:
Hello XXXXXXX and welcome to HCM.
As an Urologist and transplant surgeon,i can understand your concern.

As per the results of the testing for donor,this transplant should not be done.
It's an indication that,a rejection is the likely outcome,due to incompatibility.

DSA is donor specific antibodies. They're subdivided into further classes.
A class II positive report,suggests high rate of kidney getting rejected.

PRA is panel reactive antibodies. They're also further subdivided into classes.
A positive report again shows,incompatibility between donor and recipient.
Therefore it's easy to understand the reasons,why this donor is unsuitable.

CDC is done to know if,any infectious,viral,fungal diseases is present.
This is for organ and tissue safety,so that the organ's protected.

Hope your query is cleared.
If satisfied,you may also rate the answer.
Wish you good health.

Dr.Matthew J. Mangat.

Above answer was peer-reviewed by : Dr. Raju A.T
doctor
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Follow up: Dr. Matthew J. Mangat (1 hour later)
Thanks Doctor for detailed reply.
I just wanted to know if the recipient is on heavy Antibiotics for the last almost a month. Antibiotics like Vancomycin (500mg), Fortom (1gm), Durataz (2.25gm x 3 times a day), Amoxycilin (1.2 gm x 2 times a day) to treat different infection like Urine infection, Throat infection, Blood infection due to Perma catheter. Are there any chances that DSA and PRA may change if the test is repeated 2 -3 weeks after the antibiotics course is done ?

Also does DSA and PRA change with changing donor ?

Durataz Salt is "Piperacillin and Tazobactam"
doctor
Answered by Dr. Matthew J. Mangat (37 minutes later)
Brief Answer:
DSA and PRA are donor specific compatibility tests.

Detailed Answer:
Hi XXXXXXX

1. Antibiotics doesn't cause any difference in these tests.

2. DSA and PRA are donor specific tests for compatibility.

3. Yes,Durataz is correct information,given in severe infections.

Hope your queries are answered.
You may rate the answers on the site.
Wish your wife well.

Dr.Matthew J. Mangat.
Above answer was peer-reviewed by : Dr. Vaishalee Punj
doctor
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Follow up: Dr. Matthew J. Mangat (28 minutes later)
That means if we change donor....PRA and DSA might change ?
doctor
Answered by Dr. Matthew J. Mangat (1 hour later)
Brief Answer:
Compatibility tests is, to know suitability of organ donation.

Detailed Answer:
Hi XXXXXXX

Both the tests are to check if,the donor's kidney will be compatible for transplant.
If they come as negative,it means that compatibility is there.
Compatibility is to know if the organ is suitable and chance of rejection is present.
If negative,it means a suitable organ and rejection chance is less.

So any potential donor must undergo these tests.
If you're doing the tests for another donor,send the reports here in my name.
It should be sent as a direct question to me.
I shall clear your doubts,if your nephrologist or Urologist,doesn't do so.

Wish you well.
Dr.Matthew J. Mangat.


Above answer was peer-reviewed by : Dr. Vaishalee Punj
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Answered by
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Dr. Matthew J. Mangat

Urologist

Practicing since :1981

Answered : 1898 Questions

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Do The Following Test Reports Suggest Kidney Transplant?

Brief Answer: Reports point to incompatibility of transplant. Detailed Answer: Hello XXXXXXX and welcome to HCM. As an Urologist and transplant surgeon,i can understand your concern. As per the results of the testing for donor,this transplant should not be done. It's an indication that,a rejection is the likely outcome,due to incompatibility. DSA is donor specific antibodies. They're subdivided into further classes. A class II positive report,suggests high rate of kidney getting rejected. PRA is panel reactive antibodies. They're also further subdivided into classes. A positive report again shows,incompatibility between donor and recipient. Therefore it's easy to understand the reasons,why this donor is unsuitable. CDC is done to know if,any infectious,viral,fungal diseases is present. This is for organ and tissue safety,so that the organ's protected. Hope your query is cleared. If satisfied,you may also rate the answer. Wish you good health. Dr.Matthew J. Mangat.