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Do steroid hormone receptors die after getting into the nucleus?

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Posted on Tue, 11 Mar 2014
Question: Hi, i have a question regarding steroid hormone receptors after they go to nucleus to up regulate genes. Do they die after this event? Secondly what is the fate of receptors that are not met by their hormone...do they also die off and new ones created?
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Answered by Dr. Shehzad Topiwala (2 days later)
Brief Answer: Yes Detailed Answer: Normal human physiology is in a dynamic state. Steroid hormone receptors are naturally scavenged by the body's well regulated systems that keep receptors and ligands in balance. The receptors that are not met by the ligand also undergo a constant turnover. New ones are continuously generated as long as the body is in good health and there is no disease process like a hormonal imbalance that affects the number of these receptors expressed on nuclei. There are many 'orphan' receptors whose ligands have not yet been discovered
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Follow up: Dr. Shehzad Topiwala (47 hours later)
Dear Dr Topiwala, Thank you for your valued advice. I had some steroids treatment (oxandrolone) during early puberty, and studies suggest this possibly increased ghrh receptors at pitutary somatroph site - and this was the reason for increased gh levels during the treatment. How quickly do these ghrh receptors die off/turnover? Another doctor suggested ghrh receptors stay alive forever. Hope you can clarify for me. Thanks and Best Regards, Rony
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Answered by Dr. Shehzad Topiwala (19 hours later)
Brief Answer: Follow up Detailed Answer: Receptors are not immortal. The entire human body is in a state of constant turnover. Cells die a natural death ('apoptosis') and are replaced continually. This renewal process is present in many organ systems of the body, such as the skin and gut. Receptors are no exception. They are continuously internalized into the cell and renewed based on the body's needs or in response to specific signals
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Dr. Shehzad Topiwala

Endocrinologist

Practicing since :2001

Answered : 1663 Questions

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Do steroid hormone receptors die after getting into the nucleus?

Brief Answer: Yes Detailed Answer: Normal human physiology is in a dynamic state. Steroid hormone receptors are naturally scavenged by the body's well regulated systems that keep receptors and ligands in balance. The receptors that are not met by the ligand also undergo a constant turnover. New ones are continuously generated as long as the body is in good health and there is no disease process like a hormonal imbalance that affects the number of these receptors expressed on nuclei. There are many 'orphan' receptors whose ligands have not yet been discovered