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Dr. Andrew Rynne

Family Physician

Exp 50 years

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Do normal levels of 11-deoxycortisol indicate adequate ACTH reserves?

Answered by
Dr. Mirjeta Guni


Practicing since :2006

Answered : 2120 Questions

Posted on Wed, 12 Sep 2018 in Thyroid Problem and Hormonal Problems
Question: Hello. 10 years ago I was diagnosed with Cushing's Disease. An acth-producing adenoma was removed from my pituitary gland. Later I underwent a radiation procedure. I ended up being hypo pituitary.

My cushing's symptoms have returned, and I am going to have a lot of testing.

My 11-deoxycortisol (serum) level was in the lab's normal range. I believe this means that I have adequate ACTH reserves. Does this also mean that I must be producing acth on my own again?
Answered by Dr. Mirjeta Guni 54 minutes later
Brief Answer:

Some more info needed.

Detailed Answer:


11 deoxycortisol is not the only lab exam that confirms or rules out an overproduction of ACTh and cortisol.

You need to check ACTH and free urinary cortisol at the 24-hour urine.

The fact that 11 deoxy is within the normal ranges is a good news.

If you have other blood tests, please attach them.

Hope I have answered your query.

Take care

Dr Mirjeta Guni, Endocrinologist
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