Hi.
Thanks for asking in Healthcare Magic.

Normal sodium level is between 135 to 145 mmol/L. Hypothyroidism is one of the reasons for low sodium. Your TSH fluctuates between 3.0 to 5.0 which is on high normal side. (normal range is 0.4 to 4.5). Although your T3 is in normal range your free T4 is on the lower side. High TSH and low free T3 and T4 are suggestive of hypothyroidism.

A plasma sodium concentration of <135 mmol/L reflects hyponatremia. Altered mental status, weakness, increased thirst with the preference of ice cold water are all symptoms of hyponatremia. Lisinopril also increases sodium excretion (natriuresis) and potassium retention and may add up to your problem.

Since the underlying disorder needs to be corrected, you should consult an endocrinologist to find out the exact cause of hyponatremia and for further follow up.

I hope this helps. Please address to me if you have any further concerns.
Regards.

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Hi.
Welcome back to Healthcare Magic.

Your endocrinologist is right. The incidence of Lisinopril causing XXXXXXX hyponatremia is rare. Synthyroid is often started at a low dose and is increased every 2 to 3 weeks according to clinical response and serum TSH levels. You will get relief from your symptoms when your TSH level reaches the optimum range.

The complete response may vary in each individual depending upon the severity of the condition and so it is difficult to exactly specify the time interval and sometimes you may need an additional dose. If your dose is sufficient, then you will get relief of fatigue within 2 weeks.

Hypothyroidism per se can cause fatigue, lethargy, depression and constipation. Please continue to take Synthyroid as per your endocrinologist's specifications.

I hope I have succeeded in providing the information you are looking for. Please feel free to write back to me for further clarifications. I will be glad to help you.

Warm regards.

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