Brief Answer:
I believe you are asking 2 separate questions at the same time

Detailed Answer:
Good evening. I believe you are inadvertently asking 2 SEPARATE questions at the same time about Mg. L Threonate which is a nutritional supplement product from Life Extension as it applies to improving cognitive and memory issues.

Here's your question:

"... is it safe to take Magnesium L-threonate for better cognitive and Memory issues. If yes, then, the product from Life Extension is TRUSTABLE one ?......"


The first question is on the SAFETY of this chemical substance that is to be taken from Life Extension.

I find no dramatic or obvious DOWN SIDE to taking this supplement from a SAFETY perspective as directed on the product label. In other words, Magnesium L threonate taken in an otherwise, healthy and uncompromised individual as directed by the product label is considered to be safe.

However, more to what I believe you are really interested in knowing is the second part of your STATEMENT on "better cognitive and memory issues."

I've reviewed the major literature published since 2010 on Magnesium L threonate and the actual UTILITY of this compound on MEMORY and COGNITIVE issues is only going to be relevant in the human condition in cases where the subject is actually magnesium DEFICIENT. The actual major experiments carried out in a scientifically rigorous manner on the compound were done on RODENTS and not human beings. The results demonstrated on "memory improvements" were very specific to a very specific type of CELLULAR MEMORY.....not necessarily the "memory" that the public thinks about when they are thinking in terms of Alzheimer's Disease, normal "forgetfulness" which most people will say they occasionally experience which is not really considered pathological, etc. Also, in these rodent experiments the amount of time it took to raise magnesium levels in the brain following administration of the compound was at least 1 month of time.

Therefore, there are no well controlled human studies that this compound (in a person who is not otherwise, magnesium DEFICIENT, has any positive or measurable effect on overall COGNITIVE FUNCTION so as to IMPROVE MEMORY...in the common sense of the word MEMORY for most lay persons. Any claim made on that basis is by indirect extension from animal experiments and the experiments were those looking at rather specific forms of CELLULAR BIOCHEMICAL MEMORIES but NOT the function or of any characteristic of memory in the Behavioral Scientic point of view which is what most consumers are really thinking about when they take such supplements at early...or even elderly ages...thinking that they may enhance, improve, bolster, or even REVERSE memory/cognitive deficits.

Such evidence is lacking on this compound when discussing people with normal magnesium blood levels which can only be obtained through serum testing and should include both TOTAL as well as FREE magnesium levels.

In summary:

1. There are no significant SAFETY concerns in taking this nutritional compound if you are an otherwise, healthy individual if ingested according to labeling instructions by the company. If the person is known to be magnesium deficient then, this form of magnesium MAY raise brain magnesium levels after about 1 month of taking the supplement but based upon ANIMAL MODELS (not for actual testing) which may raise very specific cellular or biochemical "memory" for a particular behavior as defined in the animal studies. In fact, this form of magnesium as opposed to IV formulations or other types of magnesium tablets XXXXXXX actually be slightly safer if the goal were to increase brain levels of magnesium since it happens so slowly but in a consistent and predictable pattern.

2. There are no human studies done on this compound that scientifically prove the actual utility to individuals as far as their general function of MEMORY/COGNITIVE characteristics are concerned which go to the more general and expected definitions of what most lay people think when they hear the phrase "memory improvement" or "memory enhancement agent"....etc. The major studies that can scientifically make the claims of memory function alteration are doing so in rodents...not humans....and specifically have to do with a biochemical memory that is improved or enhanced resulting in a certain behavior of the animal when it comes to a function of TASTE AVERSION.....It is not relevant or applicable to the type of memory we think of in the human condition that people are concerned about such as long and short term memory, overall cognitive function that allows people to plan, implement, execute, and multitask in their daily lives in order to function at high levels both at work and at home.

I'm afraid the nutritional supplement industry is playing on words because they know what the consumer's notion of MEMORY is and what the scientific definition or implication is when doing experiments testing "memory".

There are no scientifically proven substances or compounds known to enhance, improve, or otherwise, REVERSE GLOBAL COGNITIVE FUNCTION in so far as MEMORY is concerned....and especially in an individual who is not DEFICIENT in the important nutritional elements such as Vitamin B12, folate, Vitamin D, Vitamin B1, and Thyroid hormonal production and balance, as defined by neurological and metabolic disease states.

There have been experiments performed using conventional Alzheimer's drugs for example trying to answer the question whether or not these medication could be used at earlier stages of cognitive decline or dysfunction, long before a person gets to a point of being diagnosed with an infirmity having to do with memory degeneration. Those experiments never showed any utility or benefit in taking these drugs for people who were not suffering from dementia.

If I've provided useful and helpful information to your questions could you do me a huge favor by CLOSING THE QUERY and be sure to include some fine words of feedback along with a 5 STAR rating? Again, many thanks for submitting your inquiry and please let me know how things turn out.

Do not forget to contact me in the future at: www.bit.ly/drdariushsaghafi for additional questions, comments, or concerns having to do with this topic or others.

This query has utilized a total of 53 minutes of professional time in research, review, and synthesis for the purpose of formulating a return statement.

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