Question: Hi, my daughter recently had VMA spot urine catecholamines done Her results were as follows: everything within normal ranges except: urine creatinine 3609 umol/ml and 5-hiaa 13 (normal range 5-7). It said at bottom of urine report that creatinine was measured in mmol/mol. She is aged 10, has sporadic blood pressure (145/100at highest ) and headaches, abdomen discomfort, foul smelling diarrhaoea, consistently. She has a PFO in her heart but it isn't significant.Her paediatrician doesn't seem concerned because ultrasound of kidneys seems fine. Could there be a problem? Very worried mum. Her younger sister aged 9, also has had severe bilateral pain in the long bones/muscles of her limbs - arms and legs for past two years only on exertion, and still undiagnosed. her bloods were all normal except her creatinine : 77 and again, also urine creatinine in thousands range. She also has itchy, spots that occur only on her face and hands and has PAC's in the heart, but not significant. Could there be a link between the two girls?

Thanks so much for that. I wonder if you know if there are any paediatric metabolic/endocrinologist specialists on this site that could help me narrow down what types of disorders could be possible? If I am to ask for a referral from my GP/paediatrician I would like to give more information?

I really appreciate your advice,

God Bless
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Thank you so much Dr Uma
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