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Can Prolactin Levels Increase Due To Side Effects Of Esomeprazole And Levosulpiride?
Question: my wife is on medication for gastritis, taking sompraz l and rantac. now her prolactin level has risen to 120 increase in breast size and lactating and no periods. doctors suggested pregnancy test and prolactin test, her repeated pregnancy tests were negative after the test doctor said she has a pituitary tumour and advised to get MRI done...
i read on net (http://epaper.timesofindia.com/Default/Scripting/ArticleWin.asp?From=Archive&Source=Page&Skin=TOINEW&BaseHref=TOIPU/2012/05/17&PageLabel=3&EntityId=Ar00300&ViewMode=HTML) that prolactin levels can increase due to side effect of Esomeprazole and Levosulpiride which is sompraz l. will prolactin level come to normal if sompraz is discontinued.
i read on net (http://epaper.timesofindia.com/Default/Scripting/ArticleWin.asp?From=Archive&Source=Page&Skin=TOINEW&BaseHref=TOIPU/2012/05/17&PageLabel=3&EntityId=Ar00300&ViewMode=HTML) that prolactin levels can increase due to side effect of Esomeprazole and Levosulpiride which is sompraz l. will prolactin level come to normal if sompraz is discontinued.
Brief Answer:
levosulpiride is the most probable cultprit.
Detailed Answer:
Hello
Welcome to HCM.
I can understand your concerns for your wife.
Symptomatic Hyperprolactinemia due to Proton Pump Inhibitors (PPIs) like esomeprazole is very rarely reported in literature.
Whereas, levosulpiride is known to cause raised prolactin levels.
In my opinion, she should take plain sompraz. Her symptoms should resolve after stopping levosulpiride.
If the symptoms still persist, then she can go for MRI brain to rule out pituitary tumors.
There is no need to take any drug for hyperprolactinemia.
Hope this helps.
Feel free to ask further.
Take care.
Thanks.
levosulpiride is the most probable cultprit.
Detailed Answer:
Hello
Welcome to HCM.
I can understand your concerns for your wife.
Symptomatic Hyperprolactinemia due to Proton Pump Inhibitors (PPIs) like esomeprazole is very rarely reported in literature.
Whereas, levosulpiride is known to cause raised prolactin levels.
In my opinion, she should take plain sompraz. Her symptoms should resolve after stopping levosulpiride.
If the symptoms still persist, then she can go for MRI brain to rule out pituitary tumors.
There is no need to take any drug for hyperprolactinemia.
Hope this helps.
Feel free to ask further.
Take care.
Thanks.
Note: Revert back with your gynae reports to get a clear medical analysis by our expert Gynecologic Oncologist. Click here.
Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar
Answered by
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