Question: Can histamines being released in your body when a wound is healing cause itching all over your body, not just on the wound itself?

Thanks for your reply. I think I had a large amount of histomine release after a fracel treatment on my face, neck, and around my eyes. Or potentially an allergic reaction to the numbing creamed they used on my face and neck prior to treatment. The day after fraxel I began itching on my palms and soles of feet then I began itching everywhere. I also have a warm/inflamed feeling in my body, mostly my chest. The following day I woke up feeling very weak and lacking strength. The symtoms are lessening, but I'm stilling feeling minor itching and a warm inflamed feeling in my body, mostly my chest, and Im not feeling weak and fatigued anymore though. I took my temperature today and it was 99.8... My usual temp is much lower. I also had botox in my forehead, around my eyes, and in my neck bands the day before (I've had it done multiple times before)... Only the second on my neck band though. Not sure if it could be related, but thought I should mention it just incase it could be. How long does it usually take for symtoms to go away after a large histomine release or an allergic reaction. Is there anything I need to do in the meantime? Thanks.