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Can high vitamin d3 supplementation and vitamin k2 cause hypotension?

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Posted on Thu, 17 Jul 2014
Question: Since low vitamin d levels can result in hypertension, can high vitamin d3 supplementation (I take a 10,000 iu supplement 5 to 7 days a week, along with vitamin k2 as my Vit d level had been low 30s) cause hypotension? My bp usually runs around 114/62 65p and 110/59 69p but occasionally will be around 124/68 73p. I
Kdon't feel physically weak or faint.
doctor
Answered by Dr. Shehzad Topiwala (5 hours later)
Brief Answer:
Vitamin D

Detailed Answer:
I am aware of studies that suggest vitamin D supplementation may have a beneficial effect on blood pressure. However there is no published report to the best of my knowledge in world medical literature that indicates the corollary ie high vitamin D causing hypotension.
The latest guidelines recommend targeting blood levels of 30 to 50, so one should take whatever amount is necessary to keep 25 hydroxy vitamin D blood levels in the goal range.
Regardless of the amount of vitamin D supplementation taken daily, as long as blood levels are in the desirable range, one does not expect any adverse effect on blood pressure
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Follow up: Dr. Shehzad Topiwala (8 hours later)
Thank you Dr. Topiwala for your response. I am aware that the body only converts vitamin d to the active form, d3, as needed. What are the symptoms of vitamin d3 toxicity which must occur if a person supplements more than the body needs. I live in Alaska, and I know suboptimal vitamin d3 levels are widespread this far from the equator so many people here do supplement.
doctor
Answered by Dr. Shehzad Topiwala (8 hours later)
Brief Answer:
Follow up

Detailed Answer:
Acute toxicity can occur and may result in a variety of symptoms such as confusion, excessive thirst and urination, lack of appetite, vomiting, and muscle weakness. In the long term it may cause kidney stones, bone loss and pain.
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Shehzad Topiwala (19 hours later)
The symptoms you provided of toxic levels of d3 resemble symptoms of extreme dehydration. Is that the body' attempt to try to flush out the toxic excess? Since I have been supplementing vitamin k2 with the d3, my serum d3 level has finally risen to a healthy range as I have read that the k2 aids in assimilation. In the past, I have limited my d3 supplements to 4,000iu - 6,000iu daily. Just recently have been supplementing 10,000iu but instead of taking 5 to 7 days a week, I should probably just take one every other day. Since they are fat soluable, I should not be affected by high/low serum levels from day to day...right? I sure appreciate your knowledge and experience, Dr. Topiwala.
doctor
Answered by Dr. Shehzad Topiwala (7 hours later)
Brief Answer:
Second follow up

Detailed Answer:
I am not aware of any published evidence that suggest K2 aids in assimilation of vitamin D3.

25 hydroxy vitamin D blood levels are not known to fluctuate significantly on a day to day basis. They are a good measure of the body's vitamin D stores

Take whatever amount your body needs, at whatever frequency you desire (daily, weekly, monthly options available) to keep levels in the target range mentioned above
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Dr. Shehzad Topiwala

Endocrinologist

Practicing since :2001

Answered : 1663 Questions

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Can high vitamin d3 supplementation and vitamin k2 cause hypotension?

Brief Answer: Vitamin D Detailed Answer: I am aware of studies that suggest vitamin D supplementation may have a beneficial effect on blood pressure. However there is no published report to the best of my knowledge in world medical literature that indicates the corollary ie high vitamin D causing hypotension. The latest guidelines recommend targeting blood levels of 30 to 50, so one should take whatever amount is necessary to keep 25 hydroxy vitamin D blood levels in the goal range. Regardless of the amount of vitamin D supplementation taken daily, as long as blood levels are in the desirable range, one does not expect any adverse effect on blood pressure