Sign-in to Ask A Doctor - 24x7
OR
Sign in with Google
Can Antidepressants Be Taken While On Hydromorphone?
Question: Had a whipple surgery 2 years ago. On 2mg hydromorphone for cronic pancreatitis. Doc wants me on an anti depressant. Afraid of drug interactions and it may effect the last bit of pancreas I have left. Are there any safe. The difference between Ssri or tricyclics drugs
Brief Answer:
the risk for pancreatic complications is very low
Detailed Answer:
Hello,
tricyclics and SSRIs rarely cause any problems to the pancreas. The tricyclics seem to do that even less often. But the SSRIs are considered safe too. Please be aware that there are scarce reports of pancreatic problems though.
Regarding the choice between tricyclics and SSRI, I would vote against the tricyclics because they seem to have more serious side effects (including some cardiovascular ones). The SSRIs are usually very well tolerated.
Regarding the combination with hydromorphone, both drug classes may cause problems. The problems are usually related to increased sedation and dizziness. It would be like boosting some of the side effects of hydromorphone. I wouldn't expect a very serious interaction though. And, of course, the effect on any particular individual cannot be predicted.
I hope you find my comments helpful!
You can contact me again, if you'd like any clarification or further information.
Kind Regards!
the risk for pancreatic complications is very low
Detailed Answer:
Hello,
tricyclics and SSRIs rarely cause any problems to the pancreas. The tricyclics seem to do that even less often. But the SSRIs are considered safe too. Please be aware that there are scarce reports of pancreatic problems though.
Regarding the choice between tricyclics and SSRI, I would vote against the tricyclics because they seem to have more serious side effects (including some cardiovascular ones). The SSRIs are usually very well tolerated.
Regarding the combination with hydromorphone, both drug classes may cause problems. The problems are usually related to increased sedation and dizziness. It would be like boosting some of the side effects of hydromorphone. I wouldn't expect a very serious interaction though. And, of course, the effect on any particular individual cannot be predicted.
I hope you find my comments helpful!
You can contact me again, if you'd like any clarification or further information.
Kind Regards!
Note: For more detailed guidance, please consult an Internal Medicine Specialist, with your latest reports. Click here..
Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar
Answered by
Get personalised answers from verified doctor in minutes across 80+ specialties
